Colon cancer is one of the most common forms of cancer in Germany. Prof. Dr. med. Sebastian Zeißig, group leader at the DFG Research Center for Regenerative Therapies Dresden (CRTD) - Cluster of Excellence at the TU Dresden and physician at the Department of Medicine I, University Hospital Carl Gustav Carus Dresden, has now shown a decisive role of gut bacteria in the regulation of intestinal stem cells and the development of colon cancer. This discovery promises new therapies not only for cancer but for promoting regeneration of the intestine, for example after chemotherapy.
The intestinal surface is a rapidly renewing tissue, whose regeneration is driven by stem cells. Damage of these intestinal stem cells, as observed upon chemotherapy, leads to impaired regeneration of the intestine and severe illness.
Prof. Dr. med. Sebastian Zeißig
On the other hand, genetic mutations that further promote the growth of intestinal stem cells are associated with uncontrolled organ regeneration and the development of colon cancer. Tight control of intestinal stem cells is therefore required to allow for regeneration but to prevent cancer.
Sebastian Zeißig’s group has now demonstrated that bacteria within the normal gut microbiota can invade the intestinal tissue and activate an enzyme in stem cells that facilitates stem cell growth and cancer development. This discovery could form the basis of novel therapies for the prevention and treatment of colon cancer.
“In the future, bacteria engineered to block these pathways could potentially be used as probiotics which act in local manner in the intestine to inhibit the growth of colon cancer and to perhaps even prevent its development”, says Sebastian Zeißig.
Since stem cells are also critical for regeneration in the intestine, therapies that target these pathways may further help to design new drugs that reduce side effects associated with chemotherapy, radiotherapy or other causes of intestinal damage.
With his research group at the CRTD, Zeißig has already started to engineer intestinal bacteria with the goal of influencing regeneration and cancer development in the intestine. Zeißig, who is also a practicing physician at the Department of Medicine I, University Hospital Carl Gustav Carus Dresden, adds “With its focus on stem cell biology and a close link to clinical medicine, the CRTD indeed offers a unique environment for physician scientists to develop new treatments for regenerative medicine and cancer therapy.”
"Epithelial calcineurin in the control of microbiota-dependent intestinal tumor development" (NMED-A75820A)
Phone: +49 351 458 82065, e-Mail: email@example.com
Franziska Clauß | idw - Informationsdienst Wissenschaft
Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY
NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
19.07.2018 | Materials Sciences
19.07.2018 | Earth Sciences
19.07.2018 | Life Sciences