Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Blood vessels instruct brain development

24.08.2018

Neurovascular communication in the brain

Function and homeostasis of the brain relies on communication between the complex network of cells, which compose this organ. Consequently, development of the different groups of cells in the brain needs to be coordinated in time and space.


Blood vessels in red in close communication with proliferating neuronal cells in the mouse cortex at embryonic day 10

Photo: Cecilia Llao-Cid

The group of Amparo Acker-Palmer (Buchmann Institute of Molecular Life Sciences and the Institute of Cell Biology and Neuroscience, Goethe University) reported in a Research Article in the last issue of the journal Science a novel function of blood vessels in orchestrating the proper development of neuronal cellular networks in the brain.

It is known that vascularization of the brain is necessary to provide neurons and glial cells with oxygen and nutrients important for the metabolic support of neuronal networks. “For several years, we knew that the vascular and nervous systems used very similar vocabulary to develop and function and therefore we postulated that such a common vocabulary could be used to ensure that both systems co-developed in synchronicity and communicated with each other for proper brain function,” explained Acker-Palmer.

To study the communication of the blood vessels and neuronal cells the Acker-Palmer group focused on different aspects of neurovascular development. First, they used the vascularization of the mouse retina as a well-established method to investigate molecules important for vascular growth.

Using this method, they discovered that a molecule, Reelin, that had been previously shown to influence neuronal migration was also able to independently influence the growth of vessels using a very similar signaling mechanism by activating the ApoER2 receptor and the Dab1 protein expressed in endothelial cells.

A very important structure in the brain is the cerebral cortex, which plays a key role in all basic functions such as memory, attention, perception, language and consciousness. Neuronal cells in the cerebral cortex are organized in layers and this organization is established during embryonic development.

“We decided to eliminate exclusively the Reelin signaling cascade from the endothelial cells and see how this influenced the arrangement of neurons and glial cells in the cerebral cortex,” said Acker-Palmer.

Using this system, the scientists revealed the astonishing finding that endothelial cells instruct neurons as to their correct positioning in the cerebral cortex. Mechanistically, they could show that endothelial cells secrete laminins that are deposited in the extracellular matrix surrounding the vessels to anchor properly the glial cell fibers that are necessary for proper neuronal migration and for the proper development of the cerebral cortex.

In the mature brain, glial cells also wrap around the blood capillaries and prevent harmful substances from the blood stream from entering the brain. This is known as the “blood brain barrier” and it is an essential structure that develops in the brain to keep homeostasis. Importantly, Acker-Palmer and her team also showed that the same signaling cascades used by endothelial cells in the cerebral cortex to orchestrate neuronal migration are used to establish communication at the blood brain barrier.

“Several neuropsychiatric and neurodegenerative disorders have been associated with abnormal neurovascular communication. Therefore, understanding the signaling pathways and mechanisms involved in such communication is fundamental to finding new approaches for treating dementia and mental illness.”

Publication: Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system
DOI: 10.1126/science.aao2861
(Segarra et al., Science 361, eaao2861 (2018).

Picture to Download: www.uni-frankfurt.de/73456362
Caption: Blood vessels in red in close communication with proliferating neuronal cells in the mouse cortex at embryonic day 10 (Photo: Cecilia Llao-Cid).

Information: Prof. Amparo Acker-Palmer, Institute of Cellular Biology and Neuroscience, Buchmann Institute of Molecular Life Sciences, Campus Riedberg, Tel.: (069) 798-42563, Acker-Palmer@bio.uni-frankfurt.de

Wissenschaftliche Ansprechpartner:

Prof. Amparo Acker-Palmer, Institute of Cellular Biology and Neuroscience, Buchmann Institute of Molecular Life Sciences, Campus Riedberg, Tel.: (069) 798-42563, Acker-Palmer@bio.uni-frankfurt.de

Originalpublikation:

Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system
DOI: 10.1126/science.aao2861
(Segarra et al., Science 361, eaao2861 (2018).

Weitere Informationen:

https://aktuelles.uni-frankfurt.de/englisch/blood-vessels-instruct-brain-develop...

Jennifer Hohensteiner | idw - Informationsdienst Wissenschaft

More articles from Life Sciences:

nachricht Russian scientists show changes in the erythrocyte nanostructure under stress
22.02.2019 | Lobachevsky University

nachricht How the intestinal fungus Candida albicans shapes our immune system
22.02.2019 | Exzellenzcluster Präzisionsmedizin für chronische Entzündungserkrankungen

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: (Re)solving the jet/cocoon riddle of a gravitational wave event

An international research team including astronomers from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has combined radio telescopes from five continents to prove the existence of a narrow stream of material, a so-called jet, emerging from the only gravitational wave event involving two neutron stars observed so far. With its high sensitivity and excellent performance, the 100-m radio telescope in Effelsberg played an important role in the observations.

In August 2017, two neutron stars were observed colliding, producing gravitational waves that were detected by the American LIGO and European Virgo detectors....

Im Focus: Light from a roll – hybrid OLED creates innovative and functional luminous surfaces

Up to now, OLEDs have been used exclusively as a novel lighting technology for use in luminaires and lamps. However, flexible organic technology can offer much more: as an active lighting surface, it can be combined with a wide variety of materials, not just to modify but to revolutionize the functionality and design of countless existing products. To exemplify this, the Fraunhofer FEP together with the company EMDE development of light GmbH will be presenting hybrid flexible OLEDs integrated into textile designs within the EU-funded project PI-SCALE for the first time at LOPEC (March 19-21, 2019 in Munich, Germany) as examples of some of the many possible applications.

The Fraunhofer FEP, a provider of research and development services in the field of organic electronics, has long been involved in the development of...

Im Focus: Regensburg physicists watch electron transfer in a single molecule

For the first time, an international team of scientists based in Regensburg, Germany, has recorded the orbitals of single molecules in different charge states in a novel type of microscopy. The research findings are published under the title “Mapping orbital changes upon electron transfer with tunneling microscopy on insulators” in the prestigious journal “Nature”.

The building blocks of matter surrounding us are atoms and molecules. The properties of that matter, however, are often not set by these building blocks...

Im Focus: University of Konstanz gains new insights into the recent development of the human immune system

Scientists at the University of Konstanz identify fierce competition between the human immune system and bacterial pathogens

Cell biologists from the University of Konstanz shed light on a recent evolutionary process in the human immune system and publish their findings in the...

Im Focus: Transformation through Light

Laser physicists have taken snapshots of carbon molecules C₆₀ showing how they transform in intense infrared light

When carbon molecules C₆₀ are exposed to an intense infrared light, they change their ball-like structure to a more elongated version. This has now been...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Global Legal Hackathon at HAW Hamburg

11.02.2019 | Event News

The world of quantum chemistry meets in Heidelberg

30.01.2019 | Event News

Our digital society in 2040

16.01.2019 | Event News

 
Latest News

JILA researchers make coldest quantum gas of molecules

22.02.2019 | Physics and Astronomy

Understanding high efficiency of deep ultraviolet LEDs

22.02.2019 | Materials Sciences

Russian scientists show changes in the erythrocyte nanostructure under stress

22.02.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>