Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Blood vessel cells are instructed to form tube-like structures

01.09.2008
How do blood vessel cells understand that they should organise themselves in tubes and not in layers?

A research group from Uppsala University shows for the first time that a special type of “instructor” molecule is needed to accomplish this. These findings, published in the scientific journal Blood, might be an important step towards using stem cells to build new organs.

In order for a body to develop and function the cells in the body must be able to organise themselves in relation to each other. The way in which cells are arranged depends on the organ where they are located. Blood vessel cells need to form three-dimensional, tube-like structures that can transport blood. But how do blood vessel cells know that they should do that? An important part of the communication between cells and their environment is the use of growth factors. These are proteins that bind to receptors on the surface of the cell that receives the information. When the receptor in turn forms a complex with other proteins, on the inside of the cell, the read-out from the DNA can be altered. The information has “arrived”.

VEGF (vascular endothelial growth factor) is a family of closely related growth factors that control blood vessel cells throughout life. Blood vessel development in the foetus as well as later in life, for example during wound healing, is regulated by VEGF. In the present study the research group has examined how VEGF can instruct blood vessel cells to arrange themselves into a tube. The answer is that some variants of VEGF have the ability to attract another protein, an instructor molecule, which is joined together with VEGF and its reeptor. The combination of instructor molecule, VEGF and receptor results in that a specific signal is sent inside the blood vessel cells, making them form a tube. Without the instructor molecule the cells line up next to each other, in a layer.

These results may become very useful. Today stem cells are used to create new cells, organs and even tissues, that in the future might be used to for transplantation instead of donated organs. If a patient’s own stem cells are used the problem with organ rejection is avoided. But so far there has been a challenge to create three-dimensional structures from stem cells.

Our contribution can make it possible to create blood vessels from stem cells and to direct them to form a tube instead of a layer. Perhaps this knowledge can be transferred to the formation of other tube-like structures in the body, such as the lung and intestines. The perspectives for the future are very exciting, says Lena Claesson-Welsh, who has led the study.

More information:
Kerstin Henriksson
+46 18 471 48 27, +46 70 386 26 88,
kerstin.henriksson@genpat.uu.se or
Lena Welsh (at present in the US) on lena.welsh@genpat.uu.se

Anneli Waara | alfa
Further information:
http://www.uadm.uu.se
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/blood-2007-12-125856v1

Further reports about: DNA Molecule Tube VEGF blood blood vessel factor instructor molecule stem cells structures tube-like structures

More articles from Life Sciences:

nachricht Turning carbon dioxide into liquid fuel
06.08.2020 | DOE/Argonne National Laboratory

nachricht Tellurium makes the difference
06.08.2020 | Friedrich-Schiller-Universität Jena

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: ScanCut project completed: laser cutting enables more intricate plug connector designs

Scientists at the Fraunhofer Institute for Laser Technology ILT have come up with a striking new addition to contact stamping technologies in the ERDF research project ScanCut. In collaboration with industry partners from North Rhine-Westphalia, the Aachen-based team of researchers developed a hybrid manufacturing process for the laser cutting of thin-walled metal strips. This new process makes it possible to fabricate even the tiniest details of contact parts in an eco-friendly, high-precision and efficient manner.

Plug connectors are tiny and, at first glance, unremarkable – yet modern vehicles would be unable to function without them. Several thousand plug connectors...

Im Focus: New Strategy Against Osteoporosis

An international research team has found a new approach that may be able to reduce bone loss in osteoporosis and maintain bone health.

Osteoporosis is the most common age-related bone disease which affects hundreds of millions of individuals worldwide. It is estimated that one in three women...

Im Focus: AI & single-cell genomics

New software predicts cell fate

Traditional single-cell sequencing methods help to reveal insights about cellular differences and functions - but they do this with static snapshots only...

Im Focus: TU Graz Researchers synthesize nanoparticles tailored for special applications

“Core-shell” clusters pave the way for new efficient nanomaterials that make catalysts, magnetic and laser sensors or measuring devices for detecting electromagnetic radiation more efficient.

Whether in innovative high-tech materials, more powerful computer chips, pharmaceuticals or in the field of renewable energies, nanoparticles – smallest...

Im Focus: Tailored light inspired by nature

An international research team with Prof. Cornelia Denz from the Institute of Applied Physics at the University of Münster develop for the first time light fields using caustics that do not change during propagation. With the new method, the physicists cleverly exploit light structures that can be seen in rainbows or when light is transmitted through drinking glasses.

Modern applications as high resolution microsopy or micro- or nanoscale material processing require customized laser beams that do not change during...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“Conference on Laser Polishing – LaP 2020”: The final touches for surfaces

23.07.2020 | Event News

Conference radar for cybersecurity

21.07.2020 | Event News

Contact Tracing Apps against COVID-19: German National Academy Leopoldina hosts international virtual panel discussion

07.07.2020 | Event News

 
Latest News

Rare Earth Elements in Norwegian Fjords?

06.08.2020 | Earth Sciences

Anode material for safe batteries with a long cycle life

06.08.2020 | Power and Electrical Engineering

Turning carbon dioxide into liquid fuel

06.08.2020 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>