Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Blood runs deep: Lab blood vessel model sheds light on angiogenesis

31.01.2019

To provide sufficient oxygen to tissues and organs within the body, blood vessels need to sprout new offshoots to form a widespread blood supply network, much like the trunk, branches, and twigs of a tree. However, the mechanisms by which this sprouting occurs, in both normal healthy conditions and in conditions like cancer, have remained unclear.

To shed light on this issue, Prof. Yukiko T. Matsunaga's research group based at The University of Tokyo working in collaboration within the international SMMiL-E project with the team of Dr. Fabrice Soncin at CNRS in Lille, France, used a model of a blood vessel created in the lab to study how a molecule called EGFL7 is involved in blood vessel sprouting and integrity.


Prof. Yukiko T. Matsunaga's research group used a model of a blood vessel created in the lab to study how a molecule called EGFL7 is involved in blood vessel sprouting and integrity.

Credit: 2019 Yukiko Matsunaga, Institute of Industrial Science, The University of Tokyo

This new study, reported in the journal Biomaterials, reveals much about the formation of new blood vessels, a process known as angiogenesis, and suggests EGFL7 as a good target for treating diseases in which this process plays a key role.

Such research on angiogenesis is important in a clinical context. For example, when solid tumors form, they need to promote angiogenesis to obtain an adequate blood supply in order to keep growing.

Reduced integrity of blood vessels is also an issue in various diseases, such as diabetic retinopathy, in which vessels in the retina are excessively leaky and their network structure gradually deteriorates. This background prompted the teams to use their model, called a microvessel-on-a-chip, to understand angiogenesis better.

"We obtained more insight into how blood vessels form by building our own in the lab from scratch, first forming a collagen mold containing a needle that was then removed, leaving a space that was then colonized by human umbilical vein endothelial cells," corresponding author Yukiko T. Matsunaga says.

"We next examined the effects of EGFL7 by comparing two models of this type, one in which this molecule was allowed to function normally in these cells and another in which it was knocked down by siRNA."

The teams showed that an absence of EGFL7 reduced the sprouting of new blood vessels in the microvessel-on-a-chip in a manner dependent on the molecule VEGF-A. It also led to excessive production of filopodia, which are long slender structures at which new blood vessels normally emerge. Additionally, they showed that the barrier normally formed by the endothelial cells was impaired, resulting in leakage from the vessels.

"These new findings about the importance of EGFL7 could lead to effective therapies for diseases like retinopathy and cancer," lead author Ryo Usuba says. "Our work also shows the advantages of using the microvessel-on-a-chip, both for basic research on the vasculature and in pursuit of other targets of treatment for various vascular disorders."

###

The article "EGFL7 regulates sprouting angiogenesis and endothelial integrity in a human blood vessel model" is published in Biomaterials at doi: 10.1016/j.biomaterials.2019.01.022.

About Institute of Industrial Science (IIS), the University of Tokyo

Institute of Industrial Science (IIS), the University of Tokyo is one of the largest university-attached research institutes in Japan.

More than 120 research laboratories, each headed by a faculty member, comprise IIS, with more than 1,000 members including approximately 300 staff and 700 students actively engaged in education and research. Our activities cover almost all the areas of engineering disciplines. Since its foundation in 1949, IIS has worked to bridge the huge gaps that exist between academic disciplines and real-world applications.

Media Contact

Yukiko Matsunaga
mat@iis.u-tokyo.ac.jp
81-354-526-470

https://www.iis.u-tokyo.ac.jp/en/ 

Yukiko Matsunaga | EurekAlert!
Further information:
https://www.iis.u-tokyo.ac.jp/en/news/3040/
http://dx.doi.org/10.1016/j.biomaterials.2019.01.022

More articles from Life Sciences:

nachricht Identifying the blind spots of soil biodiversity
04.08.2020 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig

nachricht AI & single-cell genomics
04.08.2020 | Helmholtz Zentrum München - German Research Center for Environmental Health

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: AI & single-cell genomics

New software predicts cell fate

Traditional single-cell sequencing methods help to reveal insights about cellular differences and functions - but they do this with static snapshots only...

Im Focus: TU Graz Researchers synthesize nanoparticles tailored for special applications

“Core-shell” clusters pave the way for new efficient nanomaterials that make catalysts, magnetic and laser sensors or measuring devices for detecting electromagnetic radiation more efficient.

Whether in innovative high-tech materials, more powerful computer chips, pharmaceuticals or in the field of renewable energies, nanoparticles – smallest...

Im Focus: Tailored light inspired by nature

An international research team with Prof. Cornelia Denz from the Institute of Applied Physics at the University of Münster develop for the first time light fields using caustics that do not change during propagation. With the new method, the physicists cleverly exploit light structures that can be seen in rainbows or when light is transmitted through drinking glasses.

Modern applications as high resolution microsopy or micro- or nanoscale material processing require customized laser beams that do not change during...

Im Focus: NYUAD astrophysicist investigates the possibility of life below the surface of Mars

  • A rover expected to explore below the surface of Mars in 2022 has the potential to provide more insights
  • The findings published in Scientific Reports, Springer Nature suggests the presence of traces of water on Mars, raising the question of the possibility of a life-supporting environment

Although no life has been detected on the Martian surface, a new study from astrophysicist and research scientist at the Center for Space Science at NYU Abu...

Im Focus: Manipulating non-magnetic atoms in a chromium halide enables tuning of magnetic properties

New approach creates synthetic layered magnets with unprecedented level of control over their magnetic properties

The magnetic properties of a chromium halide can be tuned by manipulating the non-magnetic atoms in the material, a team, led by Boston College researchers,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“Conference on Laser Polishing – LaP 2020”: The final touches for surfaces

23.07.2020 | Event News

Conference radar for cybersecurity

21.07.2020 | Event News

Contact Tracing Apps against COVID-19: German National Academy Leopoldina hosts international virtual panel discussion

07.07.2020 | Event News

 
Latest News

First radio detection of an extrasolar planetary system around a main-sequence star

04.08.2020 | Physics and Astronomy

The art of making tiny holes

04.08.2020 | Physics and Astronomy

Early Mars was covered in ice sheets, not flowing rivers

04.08.2020 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>