Over the last few decades there has been an explosion in the discovery of biomarkers for diagnosis, disease monitoring, and prognostic evaluation. In the April issue of Translational Research, entitled "Biomarkers: New Tools of Modern Medicine," an international group of medical experts explores the promise and challenges of biomarker discovery and highlights the latest advances in the use of biomarkers in various diseases.
In a commentary introducing this single-topic issue, Nikolaos G. Frangogiannis, MD, The Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, notes, "Although advanced technologies and hypothesis-driven approaches fueled by the '-omics' revolution continue to provide clinicians and researchers with an expanding list of candidate markers, very few are likely to survive the test as useful clinical tools."
Given the complexity of most common conditions, Dr. Frangogiannis says that multimarker approaches assessing the major aspects of the pathophysiology of the disease may be needed. "Development and implementation of such ambitious efforts will undoubtedly face many challenges, but may eventually fulfill the visionary goal of personalized medicine," he concludes.
HIGHLIGHTS:Biomarkers: Hopes and Challenges in the Path from Discovery to Clinical Practice
These articles appear in Translational Research, The Journal of Laboratory and Clinical Medicine, Volume 159, Issue 4 (April 2012) entitled "Biomarkers: New Tools of Modern Medicine," published by Elsevier.
Andrea Allison-Williams | EurekAlert!
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