Over the last few decades there has been an explosion in the discovery of biomarkers for diagnosis, disease monitoring, and prognostic evaluation. In the April issue of Translational Research, entitled "Biomarkers: New Tools of Modern Medicine," an international group of medical experts explores the promise and challenges of biomarker discovery and highlights the latest advances in the use of biomarkers in various diseases.
In a commentary introducing this single-topic issue, Nikolaos G. Frangogiannis, MD, The Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, notes, "Although advanced technologies and hypothesis-driven approaches fueled by the '-omics' revolution continue to provide clinicians and researchers with an expanding list of candidate markers, very few are likely to survive the test as useful clinical tools."
Given the complexity of most common conditions, Dr. Frangogiannis says that multimarker approaches assessing the major aspects of the pathophysiology of the disease may be needed. "Development and implementation of such ambitious efforts will undoubtedly face many challenges, but may eventually fulfill the visionary goal of personalized medicine," he concludes.
HIGHLIGHTS:Biomarkers: Hopes and Challenges in the Path from Discovery to Clinical Practice
These articles appear in Translational Research, The Journal of Laboratory and Clinical Medicine, Volume 159, Issue 4 (April 2012) entitled "Biomarkers: New Tools of Modern Medicine," published by Elsevier.
Andrea Allison-Williams | EurekAlert!
Less animal experiments on the horizon: Multi-organ chip awarded
19.10.2018 | Fraunhofer-Institut für Werkstoff- und Strahltechnik IWS
RUDN chemist tested a new nanocatalyst for obtaining hydrogen
18.10.2018 | RUDN University
Scientists at the Max Planck Institute for Polymer Research (MPI-P) in Mainz (Germany) together with scientists from Dresden, Leipzig, Sofia (Bulgaria) and Madrid (Spain) have now developed and characterized a novel, metal-organic material which displays electrical properties mimicking those of highly crystalline silicon. The material which can easily be fabricated at room temperature could serve as a replacement for expensive conventional inorganic materials used in optoelectronics.
Silicon, a so called semiconductor, is currently widely employed for the development of components such as solar cells, LEDs or computer chips. High purity...
Augsburg chemists present a new technology for compressing, storing and transporting highly volatile gases in porous frameworks/New prospects for gas-powered vehicles
Storage of highly volatile gases has always been a major technological challenge, not least for use in the automotive sector, for, for example, methane or...
When we put water in a freezer, water molecules crystallize and form ice. This change from one phase of matter to another is called a phase transition. While this transition, and countless others that occur in nature, typically takes place at the same fixed conditions, such as the freezing point, one can ask how it can be influenced in a controlled way.
We are all familiar with such control of the freezing transition, as it is an essential ingredient in the art of making a sorbet or a slushy. To make a cold...
Thin organic layers provide machines and equipment with new functions. They enable, for example, tiny energy recuperators. In future, these will be installed...
Das Zusammenspiel aus Struktur und Dynamik bestimmt die Funktion von Proteinen, den molekularen Werkzeugen der Zelle. Durch Fortschritte in der...
17.10.2018 | Event News
16.10.2018 | Event News
02.10.2018 | Event News
19.10.2018 | Earth Sciences
19.10.2018 | Life Sciences
19.10.2018 | Health and Medicine