Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Biological fingerprints improve diagnosis of dementia

05.10.2011
Differentiating between the various forms of dementia is crucial for initiating appropriate treatment. Researchers at the Sahlgrenska Academy have discovered that the underlying diseases leave different "fingerprints" in the cerebrospinal fluid, paving the way for more reliable diagnoses.

The two most common forms of dementia are Alzheimer's disease and vascular dementia. The latter is caused by reduced circulation in the small blood vessels of the brain, which can be picked up in brain scans as small infarcts – strokes – or widespread changes in the white matter. The problem is that this small vessel disease presents very similarly to Alzheimer's disease, making it difficult in practice to distinguish between the two.

Biochemical fingerprints in CSF
Because the different diseases are treated differently, it is important to be able to make the correct diagnosis. Researcher Maria Bjerke from the Sahlgrenska Academy at the University of Gothenburg has shown in her thesis that the different forms of dementia are detectable as biochemical changes in the cerebrospinal fluid (CSF) long before any clinical symptoms emerge. The results are significant for how the most common age-related cognitive disorders are diagnosed.
Step towards better treatment
"As the CSF is in direct contact with the brain, its molecular composition can be expected to reflect the brain's metabolism," Bjerke explains. "Examining the molecular fingerprints in the CSF enables us to determine whether or not there is an ongoing pathological process".

"Mapping the biochemical differences between the various forms of dementia will help us to understand what caused the disease, which in turn will determine how the disease should be treated."
The possibility of differentiating between patients with mild cognitive disorders due to small vessel disease and patients with Alzheimer's needs to be given much greater attention, Bjerke believes, not least with a view to designing and implementing detailed treatment studies.

About dementia
Dementia is not a disease but a diagnosis for a series of symptoms that can be caused by a variety of illnesses and injuries. Two diseases account for around 90% of all cases of dementia: Alzheimer's (60-70% of cases) and vascular dementia (20-30%). More than 20,000 people in Sweden are diagnosed with dementia every year. Most of them are elderly, and around one in five people over the age of 80 is affected.

The thesis Cerebrospinal fluid biomarkers for differentiating between Alzheimer’s disease and vascular dementia was successfully defended on 9 June 2011. 


For further information, please contact: 
Maria Bjerke

Tel: +46 (0)31 343 2410


Mobile: +46 (0)706 530 260
E-mail: maria.bjerke@neuro.gu.se

Helena Aaberg | idw
Further information:
http://www.gu.se
http://gupea.ub.gu.se/handle/2077/24854

Further reports about: CSF blood vessel molecular fingerprint spinal fluid vascular dementia

More articles from Life Sciences:

nachricht Chemists create new route to PHAs: naturally degradable bioplastics
21.11.2019 | Colorado State University

nachricht Scientists first to develop rapid cell division in marine sponges
21.11.2019 | Florida Atlantic University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Machine learning microscope adapts lighting to improve diagnosis

Prototype microscope teaches itself the best illumination settings for diagnosing malaria

Engineers at Duke University have developed a microscope that adapts its lighting angles, colors and patterns while teaching itself the optimal...

Im Focus: Small particles, big effects: How graphene nanoparticles improve the resolution of microscopes

Conventional light microscopes cannot distinguish structures when they are separated by a distance smaller than, roughly, the wavelength of light. Superresolution microscopy, developed since the 1980s, lifts this limitation, using fluorescent moieties. Scientists at the Max Planck Institute for Polymer Research have now discovered that graphene nano-molecules can be used to improve this microscopy technique. These graphene nano-molecules offer a number of substantial advantages over the materials previously used, making superresolution microscopy even more versatile.

Microscopy is an important investigation method, in physics, biology, medicine, and many other sciences. However, it has one disadvantage: its resolution is...

Im Focus: Atoms don't like jumping rope

Nanooptical traps are a promising building block for quantum technologies. Austrian and German scientists have now removed an important obstacle to their practical use. They were able to show that a special form of mechanical vibration heats trapped particles in a very short time and knocks them out of the trap.

By controlling individual atoms, quantum properties can be investigated and made usable for technological applications. For about ten years, physicists have...

Im Focus: Images from NJIT's big bear solar observatory peel away layers of a stellar mystery

An international team of scientists, including three researchers from New Jersey Institute of Technology (NJIT), has shed new light on one of the central mysteries of solar physics: how energy from the Sun is transferred to the star's upper atmosphere, heating it to 1 million degrees Fahrenheit and higher in some regions, temperatures that are vastly hotter than the Sun's surface.

With new images from NJIT's Big Bear Solar Observatory (BBSO), the researchers have revealed in groundbreaking, granular detail what appears to be a likely...

Im Focus: New opportunities in additive manufacturing presented

Fraunhofer IFAM Dresden demonstrates manufacturing of copper components

The Fraunhofer Institute for Manufacturing Technology and Advanced Materials IFAM in Dresden has succeeded in using Selective Electron Beam Melting (SEBM) to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

First International Conference on Agrophotovoltaics in August 2020

15.11.2019 | Event News

Laser Symposium on Electromobility in Aachen: trends for the mobility revolution

15.11.2019 | Event News

High entropy alloys for hot turbines and tireless metal-forming presses

05.11.2019 | Event News

 
Latest News

Scientists first to develop rapid cell division in marine sponges

21.11.2019 | Life Sciences

First detection of gamma-ray burst afterglow in very-high-energy gamma light

21.11.2019 | Physics and Astronomy

Research team discovers three supermassive black holes at the core of one galaxy

21.11.2019 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>