Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Basel Scientists Are Bringing Cells on the Fast Track

06.10.2014

During cancer metastasis, immune response cells are moving in a controlled manner through the body. Researchers from the Department of Biomedicine at the University of Basel discovered novel mechanisms of cell migration by observing cells moving on lines of connective tissue. Their results, published in the journal Developmental Cell, could lead to new approaches in combatting cancer metastasis and inflammation.

Cells migrate by connecting their cytoskeleton – a network made up of proteins – to adhesion molecules which in turn get in contact with the surrounding connective tissue. In order to guide cells in a certain direction a signal from outside is needed, which leads then to cell polarization and coordinated mechanical movement. A fundamental question is how signaling pathways are regulated in time and space to facilitate directional migration of cells.


The stimulated upper cell migrates targeted in only one direction, while the not stimulated cell changes its direction periodically and migrates approximately five times slower.

University of Basel, Department of Biomedicine

Classical cell migration experiments use uniformly coated glass plates with the drawback that cells adhere very strongly to the glass surface and move randomly in any direction. This random cell movement aggravates comprehensive studies of directional cell migration.

Mimicking organisms

In their study, scientists around Prof. Olivier Pertz from the Department of Biomedicine at the University of Basel gained novel insights into the regulation of directional cell migration: Using a special procedure, 20 micrometer wide lines were fabricated on glass thereby mimicking the connective tissue environment – creating a highway for cells. In addition, cells were stimulated with a growth factor (PDGF) which led to fast cell migration in only one direction lasting for many hours.

“This shows that we can achieve robust and directional cell migration by mimicking the geometry of connective tissue as we find it in the body,” tells Olivier Pertz. Certain dot-like structures, that are always located at the front of the cell, adopt a crucial role in maintaining long term polarized cell migration.

The research results give novel insights into how signaling pathways are regulated in time and space in order to facilitate migration of cells only in one direction. The scientists describe novel concepts of cell migration, which could help to find new targets and approaches to fight cancer metastasis and inflammation. “The more insights we get into the mechanisms of cell migration, the more effectively and focused we will be able to intervene in certain pathological processes,” first author Dr. Katrin Martin comments.

Original source
Katrin Martin, Marco Vilela, Noo Li Jeon, Gaudenz Danuser, Olivier Pertz
A Growth Factor-Induced, Spatially Organizing Cytoskeletal Module Enables Rapid and Persistent Fibroblast Migration
Developmental Cell, Volume 30, Issue 6, 29 September 2014, Pages 701–716 | doi: 10.1016/j.devcel.2014.07.022

Further Information
Prof. Olivier Pertz, University of Basel, Department of Biomedicine, phone: +41 61 267 35 41, email: olivier.pertz@unibas.ch

Weitere Informationen:

http://www.cell.com/developmental-cell/abstract/S1534-5807%2814%2900488-2 - Abstract

Reto Caluori | Universität Basel

More articles from Life Sciences:

nachricht Barium ruthenate: A high-yield, easy-to-handle perovskite catalyst for the oxidation of sulfides
16.07.2018 | Tokyo Institute of Technology

nachricht The secret sulfate code that lets the bad Tau in
16.07.2018 | American Society for Biochemistry and Molecular Biology

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Subaru Telescope helps pinpoint origin of ultra-high energy neutrino

16.07.2018 | Physics and Astronomy

Barium ruthenate: A high-yield, easy-to-handle perovskite catalyst for the oxidation of sulfides

16.07.2018 | Life Sciences

New research calculates capacity of North American forests to sequester carbon

16.07.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>