Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Basel researchers succeed in cultivating cartilage from stem cells

17.04.2018

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem cells usually develop into cartilage tissue which later naturally remodels into bone tissue.


Development of cartilage tissue from mesenchymal stem cells after eight weeks in vivo: Stable cartilage tissue, indicated by red staining (left), versus development towards bone tissue (right).

Image: University of Basel, Department of Biomedicine

Even if the stem cells are induced to differentiate into cartilage cells, they spontaneously mature into a so-called “hypertrophic” state, ultimately leading to the formation of bone tissue; this is similar to the cartilaginous tissue temporarily formed after a fracture.

Inhibiting signaling pathways

Prof. Dr. Ivan Martin’s research group at the Department of Biomedicine has now been able to demonstrate that by forcing certain molecular events occurring during the embryonic development of articular cartilage it is possible to generate stable cartilage tissue from adult human mesenchymal stem cells.

This can be achieved by inhibiting the signaling pathway of a specific protein (Bone Morphogenetic Protein, BMP). The Basel team generated these results after many years of cooperation with the Novartis Institutes for Biomedical Research, which produced and supplied the inhibitors.

Specifically, the scientists investigated two highly specific BMP receptor inhibitors in a special device (microfluid platform) developed in cooperation with Politecnico di Milano. With the use of this new technology, they were able to show that the temporary blocking of specific BMP receptors ­– even if only for a limited time – is sufficient to maintain stable cartilage tissue, both in the laboratory and in a mouse model.

Embryonic cartilage formation as a model

These results open new perspectives in the regeneration of articular cartilage as well as in the establishment of stem cell-based models of cartilage development, physiology, and possibly pathology. “Importantly, we have achieved our insights by mimicking molecular processes occurring during embryonic cartilage formation,” says Ivan Martin. This confirms the vital role of “developmental engineering,” in which natural processes are mimicked to control the development and specification of adult stem and progenitor cells.

Original Source

Paola Occhetta, Sebastien Pigeot, Marco Rasponi, Boris Dasen, Arne Mehrkens, Thomas Ullrich, Ina Kramer, Sabine Guth-Gundel, Andrea Barbero, and Ivan Martin
Developmentally inspired programming of adult human mesenchymal stromal cells towards stable chondrogenesis
PNAS (2018), doi: 10.1073/pnas.1720658115

Further information

Prof. Dr. Ivan Martin, University of Basel / University Hospital Basel, Department of Biomedicine, Tel. +41 61 265 23 84, E-Mail: ivan.martin@unibas.ch

Iris Mickein | Universität Basel
Further information:
http://www.unibas.ch

More articles from Life Sciences:

nachricht Lethal combination: Drug cocktail turns off the juice to cancer cells
12.12.2018 | Universität Basel

nachricht Smelling the forest – not the trees
12.12.2018 | Universität Konstanz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

Im Focus: Researchers develop method to transfer entire 2D circuits to any smooth surface

What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.

Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...

Im Focus: Three components on one chip

Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.

Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

New discoveries predict ability to forecast dementia from single molecule

12.12.2018 | Health and Medicine

CCNY-Yale researchers make shape shifting cell breakthrough

12.12.2018 | Physics and Astronomy

Pain: Perception and motor impulses arise in the brain independently of one another

12.12.2018 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>