Researchers at Dalhousie University have discovered a new technique using "computer-aided" drug design that may lead to an entirely new approach in the treatment of Alzheimer's disease (AD).
"Alzheimer's is a devastating disease for which no truly disease-modifying drugs are available. Our approach is completely novel. We explore how the human body attempts to protect itself from Alzheimer's, and then we exploit this to develop an entirely new approach to therapeutics," explained Dr. Weaver, a professor at Dalhousie University, clinical neurologist at Capital Health and IWK Health Centre, Canada Research Chair in Clinical Neuroscience, and the DMRF Irene MacDonald Sobey Chair in Curative Approaches to Alzheimer's Disease. "We are extremely excited about the results presented in this paper and believe that this may represent a new approach to the treatment of AD."
Weaver says that he and his fellow researchers have successfully identified molecules that are able to prevent the disease-producing aggregation of both beta-amyloid and tau – the two proteins whose misfolding is implicated in the causation of Alzheimer's.
"Using 'in silico' (i.e. computer-aided) drug design, we have discovered new lead molecules that may aid in the future development of disease-modifying drugs for Alzheimer's disease," said Dr. Autumn Meek whose research into Alzheimer's has been funded by the Dalhousie Medical Research Foundation's "Gunn Family Graduate Studentship in Alzheimer's Disease". She works with co-authors Dr. Weaver and Mr. Gordon Simms in the Department of Chemistry at Dalhousie.
According to the Alzheimer's Society publication "Rising Tide: The Impact of Dementia on Canadian Society", Alzheimer's disease is an ever-growing concern in Canadian society, and as the population trends toward the aged it will place an increased strain on healthcare and families alike. It is believed that within a generation, the numbers of Canadians with Alzheimer's disease will more than double, and the cost of caring for individuals afflicted with dementia will increase from $15 billion annually to $153 billion annually.
The paper "In silico search for an endogenous anti-Alzheimer's molecule – Screening amino acid metabolic pathways", published in the Canadian Journal of Chemistry.
Jenny Ryan | EurekAlert!
Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
16.11.2018 | Health and Medicine
16.11.2018 | Life Sciences
16.11.2018 | Life Sciences