Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

An injectable guidance system for nerve cells

05.04.2017

In many tissues of the human body, such as nerve tissue, the spatial organization of cells plays an important role. Nerve cells and their long protrusions assemble into nerve tracts and transport information throughout the body. When such a tissue is injured, an accurate spatial orientation of the cells facilitates the healing process. Scientists from the DWI – Leibniz Institute for Interactive Materials in Aachen developed an injectable gel, which can act as a guidance system for nerve cells. They recently published their results obtained from cell culture experiments in the journal ‚Nano Letters‘.

Inside the body, an extracellular matrix surrounds the cells. It provides mechanical support and promotes spatial tissue organization. In order to regenerate damaged tissue, an artificial matrix can temporally replace the natural extracellular matrix.


Dr.-Ing. Laura De Laporte and PhD student Jonas Rose analyze the orientation of nerve cells (red) along the paths provided by gel rods (green).

J. Hillmer, DWI

This matrix needs to mimic the natural cell environment in order to efficiently stimulate the regenerative potential of the surrounding tissue. Solid implants, however, may impair remaining healthy tissue whereas soft, injectable materials allow for a minimal invasive therapy, which is particularly beneficial for sensitive tissues, such as the spinal cord. Unfortunately, up to now, artificial soft materials did not yet reproduce the complex structures and spatial properties of natural tissues.

A team of scientists, headed by Dr.-Ing. Laura De Laporte from the DWI – Leibniz Institute for Interactive Materials, developed a new, minimal invasive material termed ‚Anisogel‘. “If you aim to enhance the regeneration of damaged spinal cord tissue, you need to come up with a new material concept,” says Jonas Rose. He is a PhD student working on the Anisogel project.

“We use micrometer-sized building blocks and assemble them into 3D hierarchically organized structures.” Anisogel consists of two gel components. Many, microscopically small, soft rod-shaped gels, incorporated with a low amount of magnetic nanoparticles, are the first component. Using a weak magnetic field, scientists can orient the gel rods, after which a very soft surrounding gel matrix is crosslinked, forming the structural guidance system.

The gel rods, being stabilized by the gel matrix, maintain their orientation, even after removal of the magnetic field. Using cell culture experiments, the researchers demonstrate that cells can easily migrate through this gel matrix, and that nerve cells and fibroblasts orient along the paths provided by this guidance system.

A low amount of one percent gel rods inside the entire Anisogel volume is proven to be sufficient to induce linear nerve growth. The material, developed by the Aachen-based scientists, is the first injectable biomaterial, which assembles into a controlled oriented structure after injection and provides a functional guidance system for cells.

„To meet the complex requirements of this approach, the project team includes researchers with very different areas of expertise,“ says Laura De Laporte, whose research is supported by a Starting Grant of the European Research Council. „This interdisciplinary work is what makes this project so fascinating.“

„Although our cell culture experiments were successful, we are prepared to go a long way to translate our Anisogel into a medical therapy. In collaboration with the Uniklinik RWTH Aachen, we currently plan pre-clinical studies to further test and optimize this material.“

With its work on bioactive materials, the DWI – Leibniz Institute for Interactive Materials contributes to the research network ‚Leibniz Health Technologies’. Within this network, 14 institutes of the Leibniz Association work on specific technical solutions for urgent medical problems. The network’s overall motivation is to improve medical treatment of patients. Its interdisciplinary approach aims to coalesce prevention, diagnostics and therapy, thereby increasing the health-related quality of life.

Publication:
Rose, J. C., Cámara-Torres, M., Rahimi, K., Köhler, J., Möller, M., & De Laporte, L. (2017). Nerve Cells Decide to Orient inside an Injectable Hydrogel with Minimal Structural Guidance. Nano Letters.

Dr. Janine Hillmer | idw - Informationsdienst Wissenschaft
Further information:
http://www.dwi.rwth-aachen.de

More articles from Life Sciences:

nachricht NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation

nachricht Pollen taxi for bacteria
18.07.2018 | Technische Universität München

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

NYSCF researchers develop novel bioengineering technique for personalized bone grafts

18.07.2018 | Life Sciences

Machine-learning predicted a superhard and high-energy-density tungsten nitride

18.07.2018 | Materials Sciences

Why might reading make myopic?

18.07.2018 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>