Researchers unravel the mystery of a sugar-coated bacterium
Researchers are studying the Caulobacter crescentus bacterium because of its developmental process and cellular cycle, which serve as models for a number of pathogenic bacteria.
They all have in common the use of polysaccharides to create a particularly effective protective envelope, or capsule. Professor Viollier's laboratory at the University of Geneva's (UNIGE) Faculty of Medicine has just unraveled the secrets of capsule formation during the cellular cycle and perhaps even identified potential Achilles' heel of bacteria. These results were published in the last edition of the eLife journal.
Silvia Ardissone, researcher in the Department of Microbiology and Molecular Medicine at UNIGE's Faculty of Medicine, works with Caulobacter crescentus, a bacterium that shows a particularly interesting cell division.
In fact, as with eukaryotic organisms, division of Caulobacter cells generates two different daughter cells, which can be easily separated. Researchers take advantage of this feature to obtain populations of synchronized bacteria that can be used to study specific cell cycle processes.
The sugar capsule, typical of pathogens
Like other bacteria, including several pathogenic species, Caulobacter crescentus presents a capsular envelope made of polysaccharides (sugars). This envelope protects bacteria from viruses, as well as from the human immune system. Professor Patrick Viollier's team studies how cells produce the capsule at the right time and just identified some of the underlying regulatory mechanisms.
One of the daughter cells lacks the capsule
Of the two different daughter cells generated by Caulobacter at each cell division only one is equipped with the capsule. This is what scientists noticed, and now they can now explain the reasons behind such a difference. In fact, the researchers showed that the synthesis of the capsule is controlled by the same mechanisms that regulate the cell cycle, and identified the protein that inhibits the production of the sugar capsule in one of the daughter cells.
"An uncharted path seems to have opened for the development of a new kind of antibiotics, products that would imitate the action of this inhibitory protein," comments Silvia Ardissone, who also imagines a type of medicine that "would strip the pathogens," and therefore disarm an entire bacteriological spectrum.
Silvia Ardissone | EurekAlert!
Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY
NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
20.07.2018 | Power and Electrical Engineering
20.07.2018 | Information Technology
20.07.2018 | Materials Sciences