Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A study demonstrates that p38 protein regulates the formation of new blood vessels

17.07.2019

A study performed at the Institute for Research in Biomedicine (IRB Barcelona) and published in the journal Nature Communications demonstrates that inhibition of the p38 protein boosts the formation of blood vessels in human and mice colon cancers. Known as angiogenesis, this process is critical in fuelling cancer cells, allowing them to grow and to eventually develop metastases.

The team led by Ángel R. Nebreda, head of the Signalling and Cell Cycle Laboratory at IRB Barcelona, has shown that the activity of p38 is important in mesenchymal stem cells (MSCs), which show high plasticity and can localize around blood vessels.


Structure of a blood vessel.

Credit: Raquel Batlle, IRB Barcelona

These cells participate in various processes, such as tumour development, and this study unveils their relevance in the regulation of angiogenesis.

The activity of p38 in cancer cells had already been described. However, until now, little was known about the role of this protein in MSCs and even less about its involvement in angiogenesis.

The objective of this study was to examine the role of p38 in new blood vessel formation during tumorigenesis, in particular considering the contribution of MSCs.

In this regard, as explained by Nebreda, ICREA researcher at IRB Barcelona, the study demonstrates that "p38 represses angiogenesis by exerting its action specifically in MSCs. Using genetic mouse models, we show that the inhibition of p38 stimulates the formation of new blood vessels both in tumours and during the repair of damaged tissue".

The conclusions of this study shed light on the mechanisms that regulate blood vessel formation and may have implications for the optimisation of chemotherapy-based cancer treatments, as well as for the treatment of diseases involving compromised angiogenesis.

"We hope that the biological knowledge that our work has generated can contribute to the development of more efficient therapies," concludes Raquel Batlle, postdoctoral fellow at IRB Barcelona and first author of the study.

###

The research has been funded by the European Research Council, the Fundación Olga Torres, the Marató de TV3, the Ministry of Science, Innovation and Universities, and AGAUR (Agency for Management of University and Research Grants).

Reference article:

Raquel Batlle, Eva Andrés, Lorena Gonzalez, Elisabet Llonch, Ana Igea, Núria Gutierrez-Prat, Antoni Berenguer-Llergo and Angel R. Nebreda
Regulation of tumor angiogenesis and mesenchymal-endothelial transition by p38α through TGF-β and JNK signaling
Nature Communications (2019) DOI: 10.1038/s41467-019-10946-y

Media Contact

Communications IRB Barcelona
communications@irbbarcelona.org

http://www.irbbarcelona.org 

Communications IRB Barcelona | EurekAlert!
Further information:
https://www.irbbarcelona.org/en/news/a-study-demonstrates-that-p38-protein-regulates-the-formation-of-new-blood-vessels-in-tumours
http://dx.doi.org/10.1038/s41467-019-10946-y

More articles from Life Sciences:

nachricht Numbers count in the genetics of moles and melanomas
16.08.2019 | University of Queensland

nachricht Working out why plants get sick
16.08.2019 | Institut für Pflanzenbiochemie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A miniature stretchable pump for the next generation of soft robots

Soft robots have a distinct advantage over their rigid forebears: they can adapt to complex environments, handle fragile objects and interact safely with humans. Made from silicone, rubber or other stretchable polymers, they are ideal for use in rehabilitation exoskeletons and robotic clothing. Soft bio-inspired robots could one day be deployed to explore remote or dangerous environments.

Most soft robots are actuated by rigid, noisy pumps that push fluids into the machines' moving parts. Because they are connected to these bulky pumps by tubes,...

Im Focus: Vehicle Emissions: New sensor technology to improve air quality in cities

Researchers at TU Graz are working together with European partners on new possibilities of measuring vehicle emissions.

Today, air pollution is one of the biggest challenges facing European cities. As part of the Horizon 2020 research project CARES (City Air Remote Emission...

Im Focus: Self healing robots that "feel pain"

Over the next three years, researchers from the Vrije Universiteit Brussel, University of Cambridge, École Supérieure de Physique et de Chimie Industrielles de la ville de Paris (ESPCI-Paris) and Empa will be working together with the Dutch Polymer manufacturer SupraPolix on the next generation of robots: (soft) robots that ‘feel pain’ and heal themselves. The partners can count on 3 million Euro in support from the European Commission.

Soon robots will not only be found in factories and laboratories, but will be assisting us in our immediate environment. They will help us in the household, to...

Im Focus: Scientists create the world's thinnest gold

Scientists at the University of Leeds have created a new form of gold which is just two atoms thick - the thinnest unsupported gold ever created.

The researchers measured the thickness of the gold to be 0.47 nanometres - that is one million times thinner than a human finger nail. The material is regarded...

Im Focus: Study on attosecond timescale casts new light on electron dynamics in transition metals

An international team of scientists involving the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) in Hamburg has unraveled the light-induced electron-localization dynamics in transition metals at the attosecond timescale. The team investigated for the first time the many-body electron dynamics in transition metals before thermalization sets in. Their work has now appeared in Nature Physics.

The researchers from ETH Zurich (Switzerland), the MPSD (Germany), the Center for Computational Sciences of University of Tsukuba (Japan) and the Center for...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

The power of thought – the key to success: CYBATHLON BCI Series 2019

16.08.2019 | Event News

4th Hybrid Materials and Structures 2020 28 - 29 April 2020, Karlsruhe, Germany

14.08.2019 | Event News

What will the digital city of the future look like? City Science Summit on 1st and 2nd October 2019 in Hamburg

12.08.2019 | Event News

 
Latest News

Working out why plants get sick

16.08.2019 | Life Sciences

Newfound superconductor material could be the 'silicon of quantum computers'

16.08.2019 | Physics and Astronomy

Stanford develops wireless sensors that stick to the skin to track our health

16.08.2019 | Medical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>