For proper assembly and function of cilia, they need to be supplied with the appropriate building blocks. Scientists at the MPI of Biochemistry (MPIB) in Martinsried near Munich, Germany, now identified the mechanism of how Tubulin, the main building block of cilia, is transported within the cilium. The results now published in the journal Science could help to understand and potentially prevent these diseases.
Building blocks for the assembly of a cilium are transported from the base to the tip of the cilium.
Copyright: Institut Pasteur, Paris
Although cilia fulfill various tasks, they all have a similar structure: They are only five to ten micrometers (0.0005 to 0.001 centimeters) long and are located on the surface of eukaryotic cells. About 600 different ciliary proteins are synthesized inside the cell and then transported into the cilium. Disruption of this transport system, which scientists call intraflagellar transport (IFT), can lead to errors during the assembly of the cilia and thus cause diseases resulting in mental and physical symptoms. Mistakes in ciliary function can for example cause a “situs inversus”, a condition where the left/right arrangement of the inner organs in the body is reversed.
Even though the importance of the intraflagellar transport (IFT) and the cilium to human health has been known for a long time, a structural and mechanistic understanding of IFT has been missing so far. Scientists from the research group “Intraflagellar Transport” headed by Esben Lorentzen now succeeded in identifying the transport mechanism of the key protein Tubulin. It is the most abundant protein in the cilium and forms its backbone. “We found that the two proteins IFT74 and IFT81 work together to form a tubulin-binding module,” says Sagar Bhogaraju. When the researchers disturbed the binding of IFT74 and -81 to tubulin in human cells, it had severe impact on the formation of the cilia. “Our results provide the first glimpse into the assembly of the cilium at the molecular level,” says the biochemist.
Anja Konschak | Max-Planck-Institut
Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
16.11.2018 | Health and Medicine
16.11.2018 | Life Sciences
16.11.2018 | Life Sciences