Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Become a Marathon Runner with the Protein PGC-1α

14.05.2013
Even with a greater muscle mass, a sprinter cannot win a marathon. His specially-trained and strengthened muscles will fatigue faster than the endurance-trained muscles of a long distance runner.

The research group of Prof. Christoph Handschin of the Biozentrum, University of Basel, shows that during endurance exercise the protein PGC-1α shifts the metabolic profile in the muscle. The results are published in the current issue of the journal PNAS.

Marathon runners complete a special training program to improve their endurance capacity. Accordingly, their muscles are able to sustain the provision of energy using aerobic, hence oxygen consuming processes. Untrained athletes and also bodybuilders reach however, in a much earlier stage, a condition where their muscles produce energy without oxygen. This results in the production of lactate in the muscles. At the same time, the muscles begin to fatigue and the legs become heavy.

Less Lactate with Endurance Training

The reason for this difference: the muscles switch their metabolism during endurance training. Importantly, amongst others, the production of the protein PGC-1α is stimulated. Mice with a permanently increased PGC-1α develop the same high endurance muscles as those in trained athletes. Handschin and his team were able to show in these mice that PGC-1α prevents the formation and accumulation of lactate in the muscles.
For this, the researchers trained the mice for an hour on the treadmill. After a few minutes, the lactic acid rates increased in the untrained mice, followed by performance degradation and exhaustion. Mice with a high PGC-1α, however, maintained their performance levels until the end of the training. Their lactate levels remained low despite a high training load. "As it turned out," said Handschin, "PGC-1α changed the composition of an enzyme complex. This reduced the formation of lactate. Also, the remaining lactate in the muscle is converted and used immediately as energy substrate."

Sport Therapy for Diabetics

Also in human skeletal muscle, PGC-1α controls the balance between the formation and degradation of lactate. Disturbances in lactate metabolism are common in obese and diabetic patients. The stimulation of PGC-1α production by endurance exercise activity is therefore an important approach to improve the metabolism in these patients. This could help prevent the resulting damage and progressive physical limitations to the body caused by metabolic diseases.

Publication Details

Serge Summermatter, Gesa Santos, Joaquín Pérez-Schindler, and Christoph Handschin (2013). Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A. Proceedings of the National Academy of Sciences of the United States of America (PNAS), Published online May 6, 2013.

Further Information

Prof. Christoph Handschin, Biozentrum der Universität Basel, Wachstum und Entwicklung, Klingelbergstrasse 50/70, 4056 Basel, Tel.: +41 61 267 23 78, E-Mail: christoph.handschin@unibas.ch
Weitere Informationen:
Link to abstract: http://www.pnas.org/content/early/2013/05/01/1212976110.abstract
Link to Handschin Research Group:
http://www.biozentrum.unibas.ch/nc/research/groups-platforms/eigene-seiten/unit/handschin/?tx_x4epersdb_pi5%5BshowContentPid%5D=281
Link to original press release:
http://ow.ly/l0XVb

Anne Zimmermann | Universität Basel
Further information:
http://www.unibas.ch

Further reports about: Basel Biozentrum LDH Marathon PGC-1â PNAS Protein Runner oxygen consuming processes

More articles from Life Sciences:

nachricht NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation

nachricht Pollen taxi for bacteria
18.07.2018 | Technische Universität München

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Machine-learning predicted a superhard and high-energy-density tungsten nitride

18.07.2018 | Materials Sciences

NYSCF researchers develop novel bioengineering technique for personalized bone grafts

18.07.2018 | Life Sciences

Why might reading make myopic?

18.07.2018 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>