Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

'Spaghetti' scaffolding could help grow skin in labs

20.10.2009
Scientists are developing new scaffolding technology which could be used to grow tissues such as skin, nerves and cartilage using 3D spaghetti-like structures. Their research is highlighted in the latest issue of Business, the quarterly highlights magazine of the Biotechnology and Biological Sciences Research Council (BBSRC).

The new structures are being developed by scientists from the University of Bristol, using proteins from alpha helices – one of the fundamental ways that strings of amino acids fold - to create long fibres called hydrogelating self assembling fibres (hSAFs), or hydrogels. By learning how to build hSAFs from scratch, the researchers are starting to understand how they might use these 3D scaffolds to support the growth of nerves, blood vessels and cartilage tailored to the needs of individual patients.

Professor Dek Woolfson who is leading the work, explains: "To make hydrogels you need something long and thin that will interact with copies of itself and form meshes, but is also water soluble. However rather than using natural proteins, which are complex, we've tried to make something as simple as possible that we fully understand using peptides and self assembling proteins."

Currently, hydrogel scaffold structures, made either synthetically or from natural resources such as seaweed, are used in everyday products from shampoos to drug capsules.

But explains, Professor Woolfson, the hSAFs his team are developing will have different uses: "The downside of using peptides or proteins is that they are expensive compared with synthetic polymers. We are almost certainly looking at high end biomedical applications, generating cells which can be used in living systems. Potential medical benefits include growing tissues such as skin, nerves and cartilage in the laboratory which will advance basic research and may lead to biomedical applications like speeding up wound healing and grafting."

Commenting on the research, BBSRC Chief Executive Professor Doug Kell, said: "This research highlights the importance of understanding how things work at a micro level and then looking at different ways to apply this knowledge to create effective solutions for tackling everyday problems, in this instance, translating basic bioscience into technology which could have very real clinical benefits for patients."

This research is featured in the latest edition of Business, the quarterly magazine of BBSRC.

Contact

BBSRC Media Office
Tracey Jewitt, Tel: 01793 414694, email: tracey.jewitt@bbsrc.ac.uk
Nancy Mendoza, Tel: 01793 413355, email: nancy.mendoza@bbsrc.ac.uk
Matt Goode, Tel: 01793 413299, email: matt.goode@bbsrc.ac.uk
NOTES TO EDITORS
This research features in the Autumn 2009 issue of Business, BBSRC's research highlights magazine.
To read the full article, visit: http://www.bbsrc.ac.uk/publications/business/2009/autumn/feature_protein

_spaghetti_tissue_engineering.html

About BBSRC

The Biotechnology and Biological Sciences Research Council (BBSRC) is the UK funding agency for research in the life sciences. Sponsored by Government, BBSRC annually invests around £450 million in a wide range of research that makes a significant contribution to the quality of life for UK citizens and supports a number of important industrial stakeholders including the agriculture, food, chemical, healthcare and pharmaceutical sectors. BBSRC carries out its mission by funding internationally competitive research, providing training in the biosciences, fostering opportunities for knowledge transfer and innovation and promoting interaction with the public and other stakeholders on issues of scientific interest in universities, centres and institutes.

The Babraham Institute, Institute for Animal Health, Institute of Food Research, John Innes Centre and Rothamsted Research are Institutes of BBSRC. The Institutes conduct long-term, mission-oriented research using specialist facilities. They have strong interactions with industry, Government departments and other end-users of their research.

Tracey Jewitt | EurekAlert!
Further information:
http://www.bbsrc.ac.uk

More articles from Life Sciences:

nachricht Brought to light – chromobodies reveal changes in endogenous protein concentration in living cells
21.09.2018 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen

nachricht A one-way street for salt
21.09.2018 | Julius-Maximilians-Universität Würzburg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists present new observations to understand the phase transition in quantum chromodynamics

The building blocks of matter in our universe were formed in the first 10 microseconds of its existence, according to the currently accepted scientific picture. After the Big Bang about 13.7 billion years ago, matter consisted mainly of quarks and gluons, two types of elementary particles whose interactions are governed by quantum chromodynamics (QCD), the theory of strong interaction. In the early universe, these particles moved (nearly) freely in a quark-gluon plasma.

This is a joint press release of University Muenster and Heidelberg as well as the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt.

Then, in a phase transition, they combined and formed hadrons, among them the building blocks of atomic nuclei, protons and neutrons. In the current issue of...

Im Focus: Patented nanostructure for solar cells: Rough optics, smooth surface

Thin-film solar cells made of crystalline silicon are inexpensive and achieve efficiencies of a good 14 percent. However, they could do even better if their shiny surfaces reflected less light. A team led by Prof. Christiane Becker from the Helmholtz-Zentrum Berlin (HZB) has now patented a sophisticated new solution to this problem.

"It is not enough simply to bring more light into the cell," says Christiane Becker. Such surface structures can even ultimately reduce the efficiency by...

Im Focus: New soft coral species discovered in Panama

A study in the journal Bulletin of Marine Science describes a new, blood-red species of octocoral found in Panama. The species in the genus Thesea was discovered in the threatened low-light reef environment on Hannibal Bank, 60 kilometers off mainland Pacific Panama, by researchers at the Smithsonian Tropical Research Institute in Panama (STRI) and the Centro de Investigación en Ciencias del Mar y Limnología (CIMAR) at the University of Costa Rica.

Scientists established the new species, Thesea dalioi, by comparing its physical traits, such as branch thickness and the bright red colony color, with the...

Im Focus: New devices based on rust could reduce excess heat in computers

Physicists explore long-distance information transmission in antiferromagnetic iron oxide

Scientists have succeeded in observing the first long-distance transfer of information in a magnetic group of materials known as antiferromagnets.

Im Focus: Finding Nemo's genes

An international team of researchers has mapped Nemo's genome

An international team of researchers has mapped Nemo's genome, providing the research community with an invaluable resource to decode the response of fish to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

"Boston calling": TU Berlin and the Weizenbaum Institute organize a conference in USA

21.09.2018 | Event News

One of the world’s most prominent strategic forums for global health held in Berlin in October 2018

03.09.2018 | Event News

4th Intelligent Materials - European Symposium on Intelligent Materials

27.08.2018 | Event News

 
Latest News

Astrophysicists measure precise rotation pattern of sun-like stars for the first time

21.09.2018 | Physics and Astronomy

Brought to light – chromobodies reveal changes in endogenous protein concentration in living cells

21.09.2018 | Life Sciences

"Boston calling": TU Berlin and the Weizenbaum Institute organize a conference in USA

21.09.2018 | Event News

VideoLinks
Science & Research
Overview of more VideoLinks >>>