The new technology could allow researchers to fit more biochemical probes onto a single biochip and reduce the cost of screening and analyzing changes associated with disease development, detecting bioterrorism agents, and other areas of research
3-D printing has gained popularity in recent years as a means for creating a variety of functional products, from tools to clothing and medical devices. Now, the concept of multi-dimensional printing has helped a team of researchers at the Advanced Science Research Center (ASRC) at the Graduate Center of the City University of New York develop a new, potentially more efficient and cost-effective method for preparing biochips (also known as microarrays), which are used to screen for and analyze biological changes associated with disease development, bioterrorism agents, and other areas of research that involve biological components.
In a paper published today in the journal Chem, researchers with the ASRC's Nanoscience Initiative detail how they have combined microfluidic techniques with beam-pen lithography and photochemical surface reactions to devise a new biochip printing technique. The method involves exposing a biochip's surface to specific organic reagents, and then using a tightly focused beam of light to adhere the immobilized reagents to the chip's surface. The process allows scientists to repeatedly expose a single chip to the same or different factors and imprint the reactions onto different sections of the biochip. The result is a biochip that can accommodate more probes than is achievable with current commercial platforms.
"This is essentially a new nanoscale printer that allows us to imprint more complexity on the surface of biochip than any of the currently available commercial technologies," said Adam Braunschweig, lead researcher and associate professor with the ASRC's Nanoscience Initiative. "It will help us to gain much better understanding of how cells and biological pathways work."
An additional benefit of the new tool is that it allows researchers to reliably print on a variety of delicate materials--including glasses, metals, and lipids--on the length scale of biological interactions, and without the use of a clean room. It also allows scientists to fit more reactive probes onto a single chip. These improvements could, in theory, reduce the cost of biochip-facilitated research.
ASRC scientists are now exploring ways to fine tune their new technique for creating these biochips. "We want to be able to record even more complex surface interactions and reduce our resolution down to a single molecule," said ASRC Research Associate Carlos Carbonell, the paper's lead author. "This technique gives rise to a new method of microarray creation that should be useful to the entire field of biological 'omics' research."
Our correct name is the Advance Science Research Center at the Graduate Center of the City University of New York. For the purpose of space, Advance Science Research Center, GC/CUNY is acceptable. On second reference, ASRC is correct.
About the Graduate Center of the City University of New York
The Graduate Center of the City University of New York (CUNY) is a leader in public graduate education devoted to enhancing the public good through pioneering research, serious learning, and reasoned debate. The Graduate Center offers ambitious students more than 40 doctoral and master's programs of the highest caliber, taught by top faculty from throughout CUNY -- the world's largest public urban university. Through its more than 40 centers, institutes, and initiatives, including its Advanced Science Research Center (ASRC), the Graduate Center influences public policy and discourse and shapes innovation. The Graduate Center's extensive public programs make it a home for culture and conversation.
About The Advanced Science Research Center
The ASRC at the Graduate Center elevates scientific research and education at CUNY and beyond through initiatives in five distinctive, but increasingly interconnected disciplines: environmental sciences, nanoscience, neuroscience, photonics, and structural biology. The ASRC promotes a collaborative, interdisciplinary research culture with renowned researchers from each of the initiatives working side-by-side in the ASRC's core facilities, sharing equipment that is among the most advanced available.
Paul McQuiston | EurekAlert!
Decoding the regulation of cell survival - A major step towards preventing neurons from dying
04.10.2018 | DFG-Forschungszentrum für Regenerative Therapien TU Dresden
New Cluster of Excellence “Centre for Tactile Internet with Human-in-the-Loop” (CeTI)
28.09.2018 | Technische Universität Dresden
Innsbruck quantum physicists have constructed a diode for magnetic fields and then tested it in the laboratory. The device, developed by the research groups led by the theorist Oriol Romero-Isart and the experimental physicist Gerhard Kirchmair, could open up a number of new applications.
Electric diodes are essential electronic components that conduct electricity in one direction but prevent conduction in the opposite one. They are found at the...
Max Planck researchers revel the nano-structure of molecular trains and the reason for smooth transport in cellular antennas.
Moving around, sensing the extracellular environment, and signaling to other cells are important for a cell to function properly. Responsible for those tasks...
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
19.11.2018 | Event News
09.11.2018 | Event News
06.11.2018 | Event News
21.11.2018 | Life Sciences
21.11.2018 | Power and Electrical Engineering
21.11.2018 | Life Sciences