The new technology could allow researchers to fit more biochemical probes onto a single biochip and reduce the cost of screening and analyzing changes associated with disease development, detecting bioterrorism agents, and other areas of research
3-D printing has gained popularity in recent years as a means for creating a variety of functional products, from tools to clothing and medical devices. Now, the concept of multi-dimensional printing has helped a team of researchers at the Advanced Science Research Center (ASRC) at the Graduate Center of the City University of New York develop a new, potentially more efficient and cost-effective method for preparing biochips (also known as microarrays), which are used to screen for and analyze biological changes associated with disease development, bioterrorism agents, and other areas of research that involve biological components.
In a paper published today in the journal Chem, researchers with the ASRC's Nanoscience Initiative detail how they have combined microfluidic techniques with beam-pen lithography and photochemical surface reactions to devise a new biochip printing technique. The method involves exposing a biochip's surface to specific organic reagents, and then using a tightly focused beam of light to adhere the immobilized reagents to the chip's surface. The process allows scientists to repeatedly expose a single chip to the same or different factors and imprint the reactions onto different sections of the biochip. The result is a biochip that can accommodate more probes than is achievable with current commercial platforms.
"This is essentially a new nanoscale printer that allows us to imprint more complexity on the surface of biochip than any of the currently available commercial technologies," said Adam Braunschweig, lead researcher and associate professor with the ASRC's Nanoscience Initiative. "It will help us to gain much better understanding of how cells and biological pathways work."
An additional benefit of the new tool is that it allows researchers to reliably print on a variety of delicate materials--including glasses, metals, and lipids--on the length scale of biological interactions, and without the use of a clean room. It also allows scientists to fit more reactive probes onto a single chip. These improvements could, in theory, reduce the cost of biochip-facilitated research.
ASRC scientists are now exploring ways to fine tune their new technique for creating these biochips. "We want to be able to record even more complex surface interactions and reduce our resolution down to a single molecule," said ASRC Research Associate Carlos Carbonell, the paper's lead author. "This technique gives rise to a new method of microarray creation that should be useful to the entire field of biological 'omics' research."
Our correct name is the Advance Science Research Center at the Graduate Center of the City University of New York. For the purpose of space, Advance Science Research Center, GC/CUNY is acceptable. On second reference, ASRC is correct.
About the Graduate Center of the City University of New York
The Graduate Center of the City University of New York (CUNY) is a leader in public graduate education devoted to enhancing the public good through pioneering research, serious learning, and reasoned debate. The Graduate Center offers ambitious students more than 40 doctoral and master's programs of the highest caliber, taught by top faculty from throughout CUNY -- the world's largest public urban university. Through its more than 40 centers, institutes, and initiatives, including its Advanced Science Research Center (ASRC), the Graduate Center influences public policy and discourse and shapes innovation. The Graduate Center's extensive public programs make it a home for culture and conversation.
About The Advanced Science Research Center
The ASRC at the Graduate Center elevates scientific research and education at CUNY and beyond through initiatives in five distinctive, but increasingly interconnected disciplines: environmental sciences, nanoscience, neuroscience, photonics, and structural biology. The ASRC promotes a collaborative, interdisciplinary research culture with renowned researchers from each of the initiatives working side-by-side in the ASRC's core facilities, sharing equipment that is among the most advanced available.
Paul McQuiston | EurekAlert!
OU study expands understanding of bacterial communities for wastewater treatment system
14.05.2019 | University of Oklahoma
How do muscle and tendon connections last a lifetime? Study in the fruit fly Drosophila
04.04.2019 | Westfälische Wilhelms-Universität Münster
A new assessment of NASA's record of global temperatures revealed that the agency's estimate of Earth's long-term temperature rise in recent decades is accurate to within less than a tenth of a degree Fahrenheit, providing confidence that past and future research is correctly capturing rising surface temperatures.
The most complete assessment ever of statistical uncertainty within the GISS Surface Temperature Analysis (GISTEMP) data product shows that the annual values...
Physicists at the University of Basel are able to show for the first time how a single electron looks in an artificial atom. A newly developed method enables them to show the probability of an electron being present in a space. This allows improved control of electron spins, which could serve as the smallest information unit in a future quantum computer. The experiments were published in Physical Review Letters and the related theory in Physical Review B.
The spin of an electron is a promising candidate for use as the smallest information unit (qubit) of a quantum computer. Controlling and switching this spin or...
Engineers at the University of Tokyo continually pioneer new ways to improve battery technology. Professor Atsuo Yamada and his team recently developed a...
With a quantum coprocessor in the cloud, physicists from Innsbruck, Austria, open the door to the simulation of previously unsolvable problems in chemistry, materials research or high-energy physics. The research groups led by Rainer Blatt and Peter Zoller report in the journal Nature how they simulated particle physics phenomena on 20 quantum bits and how the quantum simulator self-verified the result for the first time.
Many scientists are currently working on investigating how quantum advantage can be exploited on hardware already available today. Three years ago, physicists...
'Quantum technologies' utilise the unique phenomena of quantum superposition and entanglement to encode and process information, with potentially profound benefits to a wide range of information technologies from communications to sensing and computing.
However a major challenge in developing these technologies is that the quantum phenomena are very fragile, and only a handful of physical systems have been...
29.04.2019 | Event News
17.04.2019 | Event News
15.04.2019 | Event News
24.05.2019 | Physics and Astronomy
24.05.2019 | Medical Engineering
24.05.2019 | Life Sciences