MU interdisciplinary team develops system for removal of birthmarks, port-wine stains, tattoos
The first laser treatments used to treat skin conditions such as benign vascular birthmarks and port-wine stains were developed more than 40 years ago. Since then, clinicians and dermatologists have seen a rise in demand for minimally invasive laser-based treatments, including tattoo removal. However, it is difficult for the laser light, which is held at a distance from the skin, to be perfectly and selectively absorbed by only the targeted birthmark or tattoo. Now, researchers from the University of Missouri have developed instruments that transmit laser light into the tissue through direct contact. The techniques developed by the interdisciplinary team can be used by dermatologists and will reduce safety concerns in laser dermatology by improving laser transmission through surface layers of the skin.
Laser techniques come with risks, including eye damage. Open-air transmission, in which the clinician holds the laser at a distance from the patient, is typical during normal dermatological procedures and presents a hazard to both the patients' and doctors' eyes. Paul J.D. Whiteside, a doctoral candidate in the MU Division of Food Systems and Bioengineering, devised a system that will not only improve the process, but will be safer for both clinicians and patients.
"The system we developed uses ultrasonic pulsation in conjunction with a clinical laser to alter the properties of skin tissues during the procedure," Whiteside said. "We've named the technique 'sonoillumination,' and we're hopeful that the procedure will be available widely in the near future."
Whiteside and his team, including adviser, Heather K. Hunt, an assistant professor of bioengineering in the MU College of Engineering, tested the sonoillumination system on porcine skin tissue samples. Using various amplitudes and pulses, the instruments they developed were tested on the samples and showed great promise for the clinical setting. Whiteside presented his technique to clinicians on April 9, 2017, at the annual conference of American Society for Laser Medicine and Surgery (ASLMS).
"Pork skin samples are very close to human skin samples, so the initial results we saw are promising for human applications," Hunt said. "'Sonoillumination' will be extremely beneficial for clinicians and the ASLMS presentation allowed us to demonstrate the system to the people who actually will be using the technology once it's commercialized."
Nicholas Golda, associate professor of dermatology and director of dermatology surgery at the MU School of Medicine, echoed the merits of the sonoillumination system and the effect it will have on dermatology.
"Our goal is to provide patients with safer, more effective treatment options that potentially lower the number of treatments needed," Golda said. "This new technology may also provide physicians with a safer, more controllable option for treating patients."
The team co-authored the paper, "Ultrasonic modulation of tissue optical properties in ex vivo porcine skin to improve transmitted transdermal laser intensity," which recently was accepted for publication by the society's journal, Lasers in Surgery and Medicine. The sonoillumination research was funded in part by a 2015 Fast Track grant from the University of Missouri System.
The team is in the planning stages of developing a start-up company to commercialize the technique. Products produced by Whiteside and the team highlight the University's impact on the state's economic development efforts, including commercialization of research conducted at Mizzou, workforce development and job growth, quality of life improvements for residents, and attracting corporations and businesses to the state. Over the last five years, companies commercializing MU technologies have secured hundreds of millions of dollars in investments and grants to advance their commercialization efforts. In 2016, the Office of Technology Management and Industry Relations reported that Mizzou received $14.9 million in revenue from more than 40 technology licenses.
The MU bioengineering department is jointly affiliated with College of Agriculture, Food and Natural Resources (CAFNR) and the College of Engineering.
Editor's Note: For more information on the patent application for sonoillumination, please see: https:/
Jeff Sossamon | EurekAlert!
Investigating cell membranes: researchers develop a substance mimicking a vital membrane component
25.05.2018 | Westfälische Wilhelms-Universität Münster
New approach: Researchers succeed in directly labelling and detecting an important RNA modification
30.04.2018 | Westfälische Wilhelms-Universität Münster
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
17.07.2018 | Information Technology
17.07.2018 | Materials Sciences
17.07.2018 | Power and Electrical Engineering