The German Federal Ministry of Education and Research provides over €300,000 for the next three years to fund a new research project at the Mainz University Medical Center. The project aims to detect dispersed tumor cells in cancer patients. Latest reports indicate that such detached cancer cells could play an important role for the early detection of cancer.
In addition to the development of novel cancer treatment strategies, early disease detection and the monitoring of patient response is highly effective in reducing mortality. "Latest findings seem to indicate that dispersed tumor cells are actually an early warning signal not only of cancer development but also of relapse following therapy," explains project manager Professor Roland Stauber. The detection of such tumor cells in the blood of cancer patients is thus of particular interest in terms of both diagnosis and prognosis. However, before this knowledge can be exploited routinely in the clinics, the development of reliable and easy-to-use detection systems is a must. Such devices need to ensure that isolated tumor cells can be reliable and dynamically detected without the need for complex prior sample preparation. Hence, during the new research project, the researchers in Mainz and their collaborative partners from industry and academia are aiming at the development of a method that allows the concentration of rare cells in patients’ blood by a novel combination of nanoparticle-based magnetic flow cytometry combined with hard drive read head detection technology. "Early detection is still the crucial factor in the fight against cancer. The strategy adopted in the MRCyte joint project is tremendously innovative and could well open up new dimensions for future treatment concepts," explains the Scientific Director of the Mainz University Medical Center, Professor Dr. Dr. Reinhard Urban.
Still, one of the main challenges prior to applying the research results from "bench to bedside" is based on the fact that cancer cells can vastly differ in terms of appearance, size, and composition compared to their healthy "sister" cells. This makes it even more difficult to reliably detect detached tumor cells. "Clearly, before our approach can be used on patients, extensive laboratory research is required," emphasizes Stauber.
"Fortunately, our experience and developed technologies obtained during a previous project supported by the Rhineland-Palatinate Trust for Innovation will help us to rationally address these caveats in order to further improve patients’ care procedures," Professor Roland Stauber is confidently looking ahead. The funding will therefore provide a decisive impetus for the implementation of innovative projects with a high practical relevance.
Petra Giegerich | idw
OU study expands understanding of bacterial communities for wastewater treatment system
14.05.2019 | University of Oklahoma
How do muscle and tendon connections last a lifetime? Study in the fruit fly Drosophila
04.04.2019 | Westfälische Wilhelms-Universität Münster
The quality of additively manufactured components depends not only on the manufacturing process, but also on the inline process control. The process control ensures a reliable coating process because it detects deviations from the target geometry immediately. At LASER World of PHOTONICS 2019, the Fraunhofer Institute for Laser Technology ILT will be demonstrating how well bi-directional sensor technology can already be used for Laser Material Deposition (LMD) in combination with commercial optics at booth A2.431.
Fraunhofer ILT has been developing optical sensor technology specifically for production measurement technology for around 10 years. In particular, its »bd-1«...
The well-known representation of chemical elements is just one example of how objects can be arranged and classified
The periodic table of elements that most chemistry books depict is only one special case. This tabular overview of the chemical elements, which goes back to...
Light can be used not only to measure materials’ properties, but also to change them. Especially interesting are those cases in which the function of a material can be modified, such as its ability to conduct electricity or to store information in its magnetic state. A team led by Andrea Cavalleri from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg used terahertz frequency light pulses to transform a non-ferroelectric material into a ferroelectric one.
Ferroelectricity is a state in which the constituent lattice “looks” in one specific direction, forming a macroscopic electrical polarisation. The ability to...
Researchers at TU Graz calculate the most accurate gravity field determination of the Earth using 1.16 billion satellite measurements. This yields valuable knowledge for climate research.
The Earth’s gravity fluctuates from place to place. Geodesists use this phenomenon to observe geodynamic and climatological processes. Using...
Discovery by Brazilian and US researchers could change the classification of two species, which appear more akin to jellyfish than was thought.
The tube anemone Isarachnanthus nocturnus is only 15 cm long but has the largest mitochondrial genome of any animal sequenced to date, with 80,923 base pairs....
29.04.2019 | Event News
17.04.2019 | Event News
15.04.2019 | Event News
19.06.2019 | Physics and Astronomy
19.06.2019 | Information Technology
19.06.2019 | Materials Sciences