A model of great ape history over the past 15 million years has been fashioned through the study of genetic variation in a large panel of humans, chimpanzees, gorillas and orangutans.
The catalog of great ape genetic diversity, the most comprehensive ever, elucidates the evolution and population histories of great apes from Africa and Indonesia. The resource will likely also aid in current and future conservation efforts which strive to preserve natural genetic diversity in populations.
More than 75 scientists and wildlife conservationists from around the world assisted the genetic analysis of 79 wild and captive-born great apes. They represent all six great ape species: chimpanzee, bonobo, Sumatran orangutan, Bornean orangutan, eastern gorilla, and western lowland gorilla, and seven subspecies. Nine human genomes were included in the sampling.
Javier Prado-Martinez, working with Tomas Marques-Bonet at the Universitat Pompeu Fabra in Barcelona, Spain, and Peter H. Sudmant, with Evan Eichler at the University of Washington in Seattle, led the project. The report appears today, July 3, in the journal Nature.
"The research provided us the deepest survey to date of great ape genetic diversity with evolutionary insights into the divergence and emergence of great-ape species," noted Eichler, a UW professor of genome sciences and a Howard Hughes Medical Institute Investigator.
Genetic variation among great apes had been largeley uncharted, due to the difficuty in obtaining genetic specimens from wild apes.
Conservationists in many countries, some of them in dangerous or isolated locations, helped in this recent effort, and the research team credits them for the success of the project.
Sudmant, a UW graduate student in genome sciences, said, "Gathering this data is critical to understanding differences between great ape species, and separating aspects of the genetic code that distinguish humans from other primates." Analysis of great ape genetic diversity is likely to reveal ways that natural selection, population growth and collapse, geographic isolation and migration, climate and geological changes, and other factors shaped primate evolution.
Sudmant added that learning more about great ape genetic diversity also contributes to knowledge about disease susceptibility among various primate species. Such questions are important to both conservation efforts and to human health. The ebola virus is responsible for thousands of gorilla and chimpanzee deaths in Africa and the origin of HIV, the virus which causes AIDs, is SIV, simian immunodeficiency virus.Sudmant works in a lab that studies both primate evolutionary biology and neuropsychiatric diseases such as autism, schizophrenia, developmental delay, and cognitive and behavioral disorders.
In a companion paper published this week in Genome Research, Sudmant and Eichler wrote that they inadvertently found the first genetic evidence in a chimpanzee of a disorder resembling Smith-Magenis syndrome, a disabling physical, mental and behavioral condition in humans. Strikingly, the veterinary records of this chimpanzee named Suzie-A, matched almost exactly to the symptoms of human Smith Magenis patients; she was overweight, rage-prone, had a curved-spine chimp and died from kidney failure.
The discovery came about while researchers were exploring and comparing the accumulation of copy number variants during great ape evolution. Copy number variants are differences between individuals, populations or species in the number of times specific segments of DNA appear. Duplication and deletion of DNA segments have re-structured the genomes of humans and great apes , and are behind many genetic diseases.
In addition to offering a view of the origins of humans and their disorders, the new resource of ape genetic diversity will help address the challenging plight of great ape species on the brink extinction. The resource provides an important tool to enable biologists to identify the origin of great apes poached for their body parts or hunted down for bush meat. The research also explains why current zoo breeding programs, which have attempted to increase the genetic diversity of captive great ape populations, have resulted in captive ape populations that are genetically dissimilar to their wild counterparts.
"By avoiding inbreeding to produce a diverse population, zoos and conservation groups may be entirely eroding genetic signals specific to certain populations in specific geographic locations in the wild," Sudmant said. One of the captive-bred apes studied by the researchers, Donald, had the genetic makeup of two distinct chimpanzee subspecies, located about 2,000 kilometers away from each other in the wild.
The research also delineates the many changes that occurred along each of the ape lineages as they became separated from each other through migration, geological change and climate events. The formation of rivers, the partition of islands from the mainland, and other natural disturbances have all served to isolate groups of apes. Isolated populations may then be exposed to a unique set of environmental pressures, resulting in population fluctuations and adaptations depending on the circumstances.
Even though early human-like species were present at the same time as the ancestors of some present day great apes, the researchers found that the evolutionary history of ancestral great ape populations was far more complex than that of humans. Compared to our closest relatives, chimpanzees, human history appears "almost boring" conclude Sudmant and his mentor Evan Eicher. The last few million years of chimpanzee evolutionary history are fraught with population explosions followed by implosions demonstrating remarkable plasticity. The reasons for these fluctuations in chimpanzee population size long before our own population explosion are still unknown however.
Sudmant said his interest in studying the great apes, and wanting to preserve great ape species, stems from the similarity of great apes to humans and their curiosity about us.
"If you look at a chimpanzee or a gorilla, those guys will look right back at you," he said, "They act just like us. We need to find ways to protect these precious species from extinction."
The two Univerity of Washington studies, Great ape genetic diversity and population history, published in Nature and, Evolution and diversity of copy number variation in the great ape lineage, published in Genome Research, are funded by NIH grant HG002385 and support from the Howard Hughes Medical Institute. Peter Sudmant is a Howard Hughes Medical Institute International Student Fellow.
Leila Gray | EurekAlert!
Upcycling of PET Bottles: New Ideas for Resource Cycles in Germany
25.06.2018 | Fraunhofer-Institut für Betriebsfestigkeit und Systemzuverlässigkeit LBF
Dry landscapes can increase disease transmission
20.06.2018 | Forschungsverbund Berlin e.V.
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
16.07.2018 | Physics and Astronomy
16.07.2018 | Life Sciences
16.07.2018 | Earth Sciences