A team coordinated by a Freiburg chemist receives 1,050,000 USD to develop an approach for studying a biopolymer
Prof. Dr. Henning Jessen has received 1,050,000 US Dollars in funding from the International Human Frontier Science Program Organization (HFSPO) for a project that combines methods from synthetic organic chemistry, technologies for releasing active substances, and approaches from cell and animal biology with the goal of developing effective tools for understanding the biopolymer polyphosphate (polyP).
Prof. Dr. Henning Jessen
The Freiburg chemist will coordinate an international research group including scientists from Stanford University, USA, and the Center for DNA Fingerprinting and Diagnostics in Hyderabad, India. The team will spend the next three years attempting to decipher the mechanisms of polyP in mammals. Special emphasis will be placed on elucidating the function of polyP in blood clotting. The findings could also enable the development of novel antibiotics.
The biopolymer polyP is a chemical substance consisting of a long chain of phosphate groups that serves important functions: In bacteria, for instance, it is involved in stress response, biofilm formation, and antibiotic resistance. It could very well also be responsible for critical processes in mammals.
Studies suggest that it plays a role in blood clotting and in the transmission of neuronal signals. Researchers still lack significant information to confirm these functions, however, because the enzyme that synthesizes polyP in human cells has not yet been identified. Moreover, it is not known how it is transported in cells.
In cooperation with Prof. Dr. Paul Wender from the USA and Dr. Rashna Bhandari from India, Jessen aims to develop new technologies for making, modifying, analyzing, and transporting polyP – first in a test tube and later in living cells. In this way, the team hopes to make a fundamental contribution to further research on the biopolymer in mammals.
The international organization HFSPO funds international cooperation and novel research approaches. Jessen’s team prevailed against more than 800 proposals submitted by applicants from 64 countries. He serves as professor of bioorganic chemistry at the University of Freiburg. His research interests revolve around the chemistry of biologically important phosphates, especially the function of special highly phosphorylated cellular signaling molecules.
Henning Jessen’s research group at the University of Freiburg
Prof. Dr. Henning Jessen
Institute of Organic Chemistry
University of Freiburg
Phone: +49 (0)761/203-6073
Rudolf-Werner Dreier | idw - Informationsdienst Wissenschaft
Reconstructing the richness of pristine oceans funded by the ERC
28.10.2019 | Johannes Gutenberg-Universität Mainz
AI for Understanding and Modelling the Earth System – International Research Team wins ERC Synergy Grant
14.10.2019 | Max-Planck-Institut für Biogeochemie
Drops of water falling on or sliding over surfaces may leave behind traces of electrical charge, causing the drops to charge themselves. Scientists at the Max Planck Institute for Polymer Research (MPI-P) in Mainz have now begun a detailed investigation into this phenomenon that accompanies us in every-day life. They developed a method to quantify the charge generation and additionally created a theoretical model to aid understanding. According to the scientists, the observed effect could be a source of generated power and an important building block for understanding frictional electricity.
Water drops sliding over non-conducting surfaces can be found everywhere in our lives: From the dripping of a coffee machine, to a rinse in the shower, to an...
90 million-year-old forest soil provides unexpected evidence for exceptionally warm climate near the South Pole in the Cretaceous
An international team of researchers led by geoscientists from the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI) have now...
The bacteria that cause tuberculosis need iron to survive. Researchers at the University of Zurich have now solved the first detailed structure of the transport protein responsible for the iron supply. When the iron transport into the bacteria is inhibited, the pathogen can no longer grow. This opens novel ways to develop targeted tuberculosis drugs.
One of the most devastating pathogens that lives inside human cells is Mycobacterium tuberculosis, the bacillus that causes tuberculosis. According to the...
An international team with the participation of Prof. Dr. Michael Kues from the Cluster of Excellence PhoenixD at Leibniz University Hannover has developed a new method for generating quantum-entangled photons in a spectral range of light that was previously inaccessible. The discovery can make the encryption of satellite-based communications much more secure in the future.
A 15-member research team from the UK, Germany and Japan has developed a new method for generating and detecting quantum-entangled photons at a wavelength of...
Together with their colleagues from the University of Würzburg, physicists from the group of Professor Alexander Szameit at the University of Rostock have devised a “funnel” for photons. Their discovery was recently published in the renowned journal Science and holds great promise for novel ultra-sensitive detectors as well as innovative applications in telecommunications and information processing.
The quantum-optical properties of light and its interaction with matter has fascinated the Rostock professor Alexander Szameit since College.
02.04.2020 | Event News
26.03.2020 | Event News
23.03.2020 | Event News
03.04.2020 | Materials Sciences
03.04.2020 | Life Sciences
03.04.2020 | Life Sciences