A research project in cartilage regeneration, in which the Institute of Orthopaedic Research and Biomechanics at Ulm University participates together with partners from eight european countries, was recently financed by the European Commission with 5.5 million Euro. Named RESTORE, the project aims to create 3D matrices incorporating smart nanomaterials to repair knee cartilage lesions thereby reducing or delaying the onset of osteoarthritis, which currently affects 242 million people worldwide.
A research project in cartilage regeneration, in which the Institute of Orthopaedic Research and Biomechanics at Ulm University participates together with partners from eight european countries, was recently financed by the European Commission with 5.5 million Euro.
Named RESTORE, the project aims to create 3D matrices incorporating smart nanomaterials to repair knee cartilage lesions thereby reducing or delaying the onset of osteoarthritis, which currently affects 242 million people worldwide.
These matrices, explains Meriem Lamghari, researcher at "Instituto de Investigação e Inovação" ( i3S) and the coordinator of this European consortium, "are tailored so that they can be implanted and fill the injury site as well as respond to the knee joint mechanical forces.
Moreover, they contain smart nanoparticles with regenerative, anti-inflammatory and anti-microbial properties.
The nanoparticles with regenerative properties can, whenever necessary, be remotely activated with non-invasive methods". For that the project's team will develop a knee brace equipped with sensors capable of activating the nanoparticles present in the implanted matrix".
The work developed by the Ulm University team, who will receive around 409 000 Euro, will concentrate on the biomechanical characterization of the matrices and on preclinical testing, explains Prof. Lutz Dürselen from the Institute of Orthopaedic Research and Biomechanics in Ulm.
RESTORE emerges following constructive discussions between orthopaedic surgeons, tissue engineers, materials researchers and cellular biologists to answer pressing clinical needs. Therefore, explains Meriem Lamghari, "we are proposing two matrices, one based on a polymer already clinically tested in the veterinary sector, namely in large animals, for large knee cartilage lesions; and another matrix generated using bioprinting technology, composed by cartilage cells of human origin to which we will also incorporate the smart nanoparticles. This matrix is more adequate for small lesions".
The consortium, which will develop the project during the next 44 months with the participation of partners from Portugal, Spain, Italy, Iceland, Norway, Sweden and Finland, will work together with the Institute of Orthopaedic Research and Biomechanics at Ulm University (Director: Prof. Anita Ignatius)
Text with material from Meriem Lamghari, Instituto de Investigação e Inovação (i3s), Universität Porto, Portugal
Prof. Dr. Lutz Dürselen: 0731/500-55333, email@example.com
Annika Bingmann | idw - Informationsdienst Wissenschaft
Reconstructing the richness of pristine oceans funded by the ERC
28.10.2019 | Johannes Gutenberg-Universität Mainz
AI for Understanding and Modelling the Earth System – International Research Team wins ERC Synergy Grant
14.10.2019 | Max-Planck-Institut für Biogeochemie
Scientists at the Fraunhofer Institute for Laser Technology ILT have come up with a striking new addition to contact stamping technologies in the ERDF research project ScanCut. In collaboration with industry partners from North Rhine-Westphalia, the Aachen-based team of researchers developed a hybrid manufacturing process for the laser cutting of thin-walled metal strips. This new process makes it possible to fabricate even the tiniest details of contact parts in an eco-friendly, high-precision and efficient manner.
Plug connectors are tiny and, at first glance, unremarkable – yet modern vehicles would be unable to function without them. Several thousand plug connectors...
An international research team has found a new approach that may be able to reduce bone loss in osteoporosis and maintain bone health.
Osteoporosis is the most common age-related bone disease which affects hundreds of millions of individuals worldwide. It is estimated that one in three women...
Traditional single-cell sequencing methods help to reveal insights about cellular differences and functions - but they do this with static snapshots only...
“Core-shell” clusters pave the way for new efficient nanomaterials that make catalysts, magnetic and laser sensors or measuring devices for detecting electromagnetic radiation more efficient.
Whether in innovative high-tech materials, more powerful computer chips, pharmaceuticals or in the field of renewable energies, nanoparticles – smallest...
An international research team with Prof. Cornelia Denz from the Institute of Applied Physics at the University of Münster develop for the first time light fields using caustics that do not change during propagation. With the new method, the physicists cleverly exploit light structures that can be seen in rainbows or when light is transmitted through drinking glasses.
Modern applications as high resolution microsopy or micro- or nanoscale material processing require customized laser beams that do not change during...
23.07.2020 | Event News
21.07.2020 | Event News
07.07.2020 | Event News
06.08.2020 | Earth Sciences
06.08.2020 | Power and Electrical Engineering
06.08.2020 | Life Sciences