Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A compound from olive-pomace oil gets 80% slowing down of HIV spread

04.12.2006
Olive oil has become part of the fight against the Human Immunodeficiency Virus (HIV) – the cause of AIDS – thanks to research carried out by the Bionat team, from the University of Granada (Universidad de Granada), headed by Prof. Andrés García-Granados, senior lecturer in Organic Chemistry.

Their work shows that maslinic acid – a natural product extracted from dry olive-pomace oil in oil mills – inhibits serin-protease, an enzyme used by HIV to release itself from the infected cell into the extracellular environment and, consequently, to spread the infection into the whole body. These scientists from Granada determined that the use of olive-pomace oil can produce an 80% slowing down in AIDS spreading in the body.

Maslinic or crataegolic acid is a pentacyclic terpene with antioxidant and anticancer effects found in wax from olive skin, alongside oleanolic acid. The effects of this compound in the fight against AIDS are simultaneously being studied in the UGR [http://www.ugr.es] and in Hospital Carlos III in Madrid by a team headed by Prof. Vallejo Nájera.

Maslinic acid innovative properties stem from its powerful protease-inhibition activity, allowing researchers from Granada to register two patents on behalf of the UGR to produce drugs for treatment of diseases caused by protozoa Cryptosporidium – a parasite causing small intestine infection and diarrhoea – and by HIV. The University of Granada has already registered almost ten other patents related to this compound’s properties. Maslinic acid is also a very active compound in opportunistic parasitic infections seriously affecting HIV patients.

In trials carried out by these researchers with the MT2 cell line, for concentrations of 25 and 30 µg/ml maslinic acid inhibited replication of a primary HIV-1 isolate. For 25 µg/ml a decrease in the cytopathic effect and in p24 antigen levels in the supernatant culture medium was detected. For 30 µg/ml, there was total absence of the cytopathic effect and also a decrease of p24 antigen levels.

Pilot Plant

The UGR Faculty of Sciences hosts a unique maslinic acid production pilot plant where the company MANINVEST S.L. – staffing scientists from the UGR departments of Organic Chemistry, Biochemistry and Parasitology, as well as a coordination economist – is carrying out research on technology implementation and business programmes tuning aimed at making manitol and maslinic and oleanolic acids programmes more profitable.

Whilst manitol is obtained from olive oil waste water (alpechín) and olive-tree leaves, both acids are extracted from dry olive-pomace oil (orujo) produced at the olive-milling stage during olive oil elaboration process.

To this day, only oleanolic acid – produced in China – has been marketed. However, maslinic acid has gained importance as it is not still on the market and has a greater biological activity.

Prof. Andrés García-Granados’s team intends to continue working in the design and implementation of new maslinic acid by-products to fight against HIV, as well as in other innovative research projects financed by the Spanish Ministry of Science and Technology and the Andalusian Regional Government.

The World AIDS Day will take place tomorrow, 1st December – it is the international day of action on HIV and AIDS, a disease affecting 39.5 million people all over the world, according to the latest data by UNAIDS and the World Health Organisation (WHO). The number of HIV infected people has decreased from 40.3 millions in 2005 to 39.5 millions in 2006, and new yearly infections have been reduced from 5 millions to 4.3 millions, according to both international organisations.

Antonio Marín Ruiz | alfa
Further information:
http://www.ugr.es
http://prensa.ugr.es/prensa/research/index.php

More articles from Agricultural and Forestry Science:

nachricht New insight into why Pierce's disease is so deadly to grapevines
11.06.2018 | University of California - Davis

nachricht Where are Europe’s last primary forests?
29.05.2018 | Humboldt-Universität zu Berlin

All articles from Agricultural and Forestry Science >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>