Scientists from Novosibirsk are engaged in the development of an unusual vaccine which, apart from being less expensive to produce, safe and painless to administer, is also edible. The research is being accomplished in the framework of the ISTC Partner Project #2176, which is funded by the Agricultural Research Service of the U.S. Department of Agriculture, and so far the project team has managed to introduce a HIV antigen protein gene into tomatoes.
Usually, vaccines are injected, but some - like the polio vaccine - can be ingested or eaten. Thus, a number of years ago plant genetic engineers started producing vaccine proteins in plants to test their effectiveness, which started a whole new area of plant derived edible vaccines. This approach has already been used to test vaccines for hepatitis viruses and some bacterial pathogens, but Dr. Sergey Shchelkunov at SRC of Virology and Biotechnology "Vector" wondered if an edible vaccine for HIV AIDS could be produced.
Dr. Shchelkunovs laboratory teamed up with other Russian scientists from both the Novosibirsk Institute of Biological Chemistry and Basic Medicine, and the Siberian Institute of Plant Physiology and Biochemistry in Irkutsk, Russia. A functional vaccine from their work is still to be tested, but as a result of project 2176 the researchers were able to insert into the chromosome of tomato plants a gene from HIV. Furthermore, they were able to show that the corresponding protein product from the HIV gene was expressed in different parts of the transgenic tomato plant including ripe fruit. And, because this is a vaccine based on a single protein from HIV, there is no risk of acquiring an HIV infection from eating the tomato fruit.
Alexander Ivanchenko | alfa
Breeders release new flaxseed cultivar with higher yield
11.09.2019 | American Society of Agronomy
Team of researchers in Vienna has decoded the structure of the ribonucleoprotein (RNP) of rabies virus
29.07.2019 | Veterinärmedizinische Universität Wien
Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Potsdam (both in Germany) and the University of Toronto (Canada) have pieced together a detailed time-lapse movie revealing all the major steps during the catalytic cycle of an enzyme. Surprisingly, the communication between the protein units is accomplished via a water-network akin to a string telephone. This communication is aligned with a ‘breathing’ motion, that is the expansion and contraction of the protein.
This time-lapse sequence of structures reveals dynamic motions as a fundamental element in the molecular foundations of biology.
Two research teams have succeeded simultaneously in measuring the long-sought Thorium nuclear transition, which enables extremely precise nuclear clocks. TU Wien (Vienna) is part of both teams.
If you want to build the most accurate clock in the world, you need something that "ticks" very fast and extremely precise. In an atomic clock, electrons are...
Researchers from Chalmers University of Technology have demonstrated a detector made from graphene that could revolutionize the sensors used in next-generation space telescopes. The findings were recently published in the scientific journal Nature Astronomy.
Beyond superconductors, there are few materials that can fulfill the requirements needed for making ultra-sensitive and fast terahertz (THz) detectors for...
A supersolid is a state of matter that can be described in simplified terms as being solid and liquid at the same time. In recent years, extensive efforts have been devoted to the detection of this exotic quantum matter. A research team led by Tilman Pfau and Tim Langen at the 5th Institute of Physics of the University of Stuttgart has succeeded in proving experimentally that the long-sought supersolid state of matter exists. The researchers report their results in Nature magazine.
In our everyday lives, we are familiar with matter existing in three different states: solid, liquid, or gas. However, if matter is cooled down to extremely...
A team headed by Prof. Steve Albrecht from the HZB will present a new world-record tandem solar cell at EU PVSEC, the world's largest international photovoltaic and solar energy conference and exhibition, in Marseille, France on September 11, 2019. This tandem solar cell combines the semiconducting materials perovskite and CIGS and achieves a certified efficiency of 23.26 per cent. One reason for this success lies in the cell’s intermediate layer of organic molecules: they self-organise to cover even rough semiconductor surfaces. Two patents have been filed for these layers.
Perovskite-based solar cells have experienced an incredibly rapid increase in efficiency over the last ten years. The combination of perovskites with classical...
10.09.2019 | Event News
04.09.2019 | Event News
29.08.2019 | Event News
13.09.2019 | Earth Sciences
13.09.2019 | Power and Electrical Engineering
13.09.2019 | Power and Electrical Engineering