For a long time an increased growth of calves in the womb and associated consequences generated severe problems for breeders and scientists.
Furthermore, many studies had proven that prenatal growth of mammals in the womb had significant consequences on life after birth.
Now scientists at the Leibniz-Institute for Farm Animal Biology (FBN) in Dummerstorf made a pioneering discovery on the inherited background of divergent fetal growth in the womb in cooperation with colleagues from the Helmholtz-Zentrum Munich, the Technical University Munich, the Kagoshima and the Shirakawa Institute in Japan. They identified a genetic mechanism in cattle that is associated with substantial variation in prenatal growth. Subject of their discovery was a genetic variant in the NCAPG gene on bovine chromosome 6, which should make a major contribution to the divergent development of fetuses in the womb (see background). The key results of the study on the background of fetal growth in cattle are published in the recent November issue of the renowned scientific Journal "Genetics" (abstract: http://www.genetics.org/cgi/content/abstract/183/3/951).
"The variant in the NCAPG gene seems evolutionary rather young, it is however already distributed across many breeds. The function of the gene in mammals has been largely unknown, although it is described to be involved in cell division in lower organism like the fruit fly", pointed out Dr. Christa Kuehn from the Research Unit Molecular Biology of the Leibniz-Institute for Farm Animal Biology .
An increased birth weight frequently results in an impaired delivery or even stillbirth of the calf. This study focussed on the question, which genetic variation is relevant for a high body weight of calves in the womb. For the first time it is possible now to detect a genetic variant via a conventional genetic test, which will enable future targeted selection in cattle to decrease the number of calves with increased birth weight (see background). Thus, the results presented in the study are relevant for both animal welfare and breeding perspectives in cattle production. Furthermore, this study also provides an important contribution to basic research. Frequently, an extreme fetal growth is associated with significant consequences in later life, e.g., increased predisposition to diabetes and obesity in humans.The Leibniz-Institute for Farm Animal Biology was in charge of major parts of the study including filing the concept, recording of phenotypes and the analysis of the results. The study itself is part of the long-term project SEGFAM dedicated to reveal causative mechanisms for divergent growth and lactation in cattle. The results presented in the current study provide an example, how the mission of the Institute to conduct application-oriented basic science is accomplished. Starting point was a problem relevant to livestock production, the increased birth weight in cattle. While tackling this issue, the elucidation of new, potentially relevant mechanisms for the regulation of fetal growth has contributed to basic research as well.
In the future, research on the NCAPG gene in cattle will focus on two directions. Firstly, the potential of the genetic test in cattle production will be further evaluated. Respective collaborations with breeding organizations are already under way. Secondly, the functional mechanisms of the NCAPG gene in mammals will be elucidated.
Background - conducting the study
In order to establish the specific resource population Charolais sires and German Holstein dams were chosen to form the founder generation (P0). Via artificial insemination and embryo transfer, a first progeny generation (F1), and subsequently by mating F1 individuals, a second progeny generation (F2) were generated. German Holstein females were recipients for both progeny generations. Embryos were collected and transferred at FBN, where also the respective calves were born. After establishing a substantial part of the resource population, an initial scan of ( oder: screen for) regions of the bovine genome relevant for fetal growth was started. From early on, the bovine chromosome 6 was outstanding compared to other parts of the bovine genome. The raw information from the initial scan on the target region on chromosome 6 was refined by fine mapping. Subsequently, the NCAPG was identified as potentially interesting gene by merging information from recent literature, own genetic maps and indication from participating colleagues in Japan and Munich. The NCAPG gene was then systematically investigated for genetic variants. Among the NCAPG variants detected was the mutation that was significantly associated with fetal growth in the womb.Genetics, Volume 183, Issue 3, November 2009
Researchers discover natural product that could lead to new class of commercial herbicide
16.07.2018 | UCLA Samueli School of Engineering
Advance warning system via cell phone app: Avoiding extreme weather damage in agriculture
12.07.2018 | Leibniz-Zentrum für Agrarlandschaftsforschung (ZALF) e.V.
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
20.07.2018 | Power and Electrical Engineering
20.07.2018 | Information Technology
20.07.2018 | Materials Sciences