Stimuli-responsive or ‘smart’ polymeric nanofibers have attracted increasing attention. The nanoscale structures give rise to high sensitivity to stimuli while they can also be manipulated easily as macroscopic materials.
Design concept for a smart hyperthermia nanofiber system that uses magnetic nanoparticles (MNPs) dispersed in temperature-responsive polymers. Anticancer drug, doxorubicin (DOX), is also incorporated into the nanofibers. The nanofibers are chemically crosslinked. First, the device signal (alternating magnetic field, AMF) is turned 'on' to activate the MNPs in the nanofibers. Then, the MNPs generate heat to collapse the polymer networks in the nanofiber, allowing the 'on-off' release of DOX. Both the generated heat and released DOX induce apoptosis of cancer cells by hyperthermic and chemotherapeutic effects, respectively.
Now researchers at the University of Tsukuba and the National Institute of Materials Science in Japan have demonstrated how they can be used to host magnetic nanoparticles to exploit hyperthermal effects for treating cancer while avoiding the usual side-effects. The incorporation of doxorubicin in the nanofibers as well allows controlled release of the anticancer drug as an additional mechanism for killing cancer cells.
Magnetic nanoparticles can kill cancer cells through the heat generated by induction when subjected to an alternating magnetic field. Such hyperthermal treatments have also been shown to improve the efficacy of anticancer drugs. However the nanoparticles can also lead to impaired mitochondrial function, inflammation, and DNA damage. Incorporating the nanoparticles into nanofibers may provide a solution.
Young-Jin Kim , Mitsuhiro Ebara , and Takao Aoyagi electrspun the fibers from a solution of the polymer poly(NIPAAm- co -HMAAm) mixed with a solution of magnetic nanoparticles and doxorubicin. The heating caused by the nanoparticles when switching on an alternating magnetic field caused hyperthermal effects, as well as reversible deswelling and deformation of the fibers, which released the drug molecules. Investigations in vitro and in cell lines demonstrated effective killing of cancer cells, which was greatly reduced for hyperthermal treatments alone in the absence of doxorubicin.
“The doxorubicin/magnetic-nanoparticles nanofi ber induced the apoptosis of cancer cells due to a synergistic effect of chemotherapy and hyperthermia,” say the authors. The work demonstrates how smart nanofibers have potential for use as a manipulative material that combines hyperthermia and drug release treatments that can be controlled with the simple switching on or off of an alternating magnetic field.Contact information
*Corresponding author: AOYAGI.Takao@nims.go.jp
Adarsh Sandhu | Research asia research news
Research finds new molecular structures in boron-based nanoclusters
13.07.2018 | Brown University
3D-Printing: Support structures to prevent vibrations in post-processing of thin-walled parts
12.07.2018 | Fraunhofer-Institut für Produktionstechnologie IPT
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
13.07.2018 | Event News
13.07.2018 | Materials Sciences
13.07.2018 | Life Sciences