Recently, a research team led by Dr. DU Xuemin at the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences created a new shape-morphing scaffold, enabling programmed deformation from a 2D planar cell-laden structure to a well-defined 3D tubular shape, which facilitated the facile 3D endothelialization of small-diameter vascular grafts.
The paper entitled "Programmed Shape-Morphing Scaffolds Enabling Facile 3D Endothelialization" was published in Advanced Functional Materials.
Cardiovascular disease is now the No. 1 cause of death globally according to the World Health Organization, and more than 17.5 million patients die from it every year.
Coronary artery bypass grafting (CABG) is one of most effective approaches for treating severe cardiovascular disease. However, patients undergoing CABG still face the high risks of transplantation surgery and potential complications caused by compliance mismatch.
In recent years, tissue engineering has emerged, holding the promise of constructing functional vascular analogs for treating cardiovascular disease. Nevertheless, 3D endothelialization remains a great challenge for tissue-engineered vascular grafts (TEVGs), particularly small-diameter ones (diameter < 5 mm) suited for CABG, and is the primary problem of TEVGs upon implantation.
To address the problem of 3D endothelialization of TEVGs, the researchers designed and developed a novel scaffold, consisting of two layers that combined a shape memory polymer and an electrospun membrane.
By employing the unique shape memory property of the polymer, the scaffold could deform from a 2D planar shape to a well-defined 3D tubular shape at the physiological temperature (37 °C).
The endothelial cells seeded firmly and homogeneously on the electrospun membrane of the planar bilayer scaffold could therefore be conveniently converted to a vascular-like structure of predetermined tubular shape, and a desirable 3D spatial organization of endothelial cells onto the lumen of the scaffold was achieved.
The study found that the 3D cultured endothelial cells on the novel shape-morphing scaffold could form biomimetic cell-scaffold and cell-cell interactions, effectively promoting the formation of a confluent endothelial monolayer and the 3D endothelialization of TEVGs.
This research not only offers a new method for creating TEVGs that enables facile 3D endothelialization, but also offers a potential in vitro endothelium model for the screening of cardiovascular drugs.
"We hope that the universal strategy developed in this study by combining smart materials and conventional tissue engineering scaffolds can be extended to engineering complex cell-scaffold constructs mimicking the complicated anatomy of various tissues and organs through on-demand programmed deformation," said Dr. DU Xuemin.
ZHANG Xiaomin | EurekAlert!
New approach improving stability and optical properties of perovskite films
14.02.2019 | City University of Hong Kong
Calculating correlated materials from first principles
14.02.2019 | Leibniz-Institut für Festkörper- und Werkstoffforschung Dresden
For the first time, an international team of scientists based in Regensburg, Germany, has recorded the orbitals of single molecules in different charge states in a novel type of microscopy. The research findings are published under the title “Mapping orbital changes upon electron transfer with tunneling microscopy on insulators” in the prestigious journal “Nature”.
The building blocks of matter surrounding us are atoms and molecules. The properties of that matter, however, are often not set by these building blocks...
Scientists at the University of Konstanz identify fierce competition between the human immune system and bacterial pathogens
Cell biologists from the University of Konstanz shed light on a recent evolutionary process in the human immune system and publish their findings in the...
Laser physicists have taken snapshots of carbon molecules C₆₀ showing how they transform in intense infrared light
When carbon molecules C₆₀ are exposed to an intense infrared light, they change their ball-like structure to a more elongated version. This has now been...
The so-called Abelian sandpile model has been studied by scientists for more than 30 years to better understand a physical phenomenon called self-organized...
Physicists from the University of Basel have developed a new method to examine the elasticity and binding properties of DNA molecules on a surface at extremely low temperatures. With a combination of cryo-force spectroscopy and computer simulations, they were able to show that DNA molecules behave like a chain of small coil springs. The researchers reported their findings in Nature Communications.
DNA is not only a popular research topic because it contains the blueprint for life – it can also be used to produce tiny components for technical applications.
11.02.2019 | Event News
30.01.2019 | Event News
16.01.2019 | Event News
15.02.2019 | Physics and Astronomy
15.02.2019 | Physics and Astronomy
15.02.2019 | Life Sciences