A biopolymer suture cleared last month by the FDA is made of materials that the human body produces naturally, so they can be safely absorbed once the wound is healed. They are also 30 percent stronger than sutures now used and very flexible, making them easier for surgeons to work with.
The sutures were developed by Tepha, Inc., a Cambridge company that hopes to use the same material to produce an array of absorbable medical devices, including stents, surgical meshes and possibly a heart valve scaffold, says Simon Williams, CEO of Tepha and a former MIT postdoctoral associate.
Williams said he envisions that the new sutures will be used for abdominal closures, which are prone to re-opening, and to stitch tendons and ligaments.
Developed using a method created at MIT, the absorbable sutures are the first made from material produced by genetically modified bacteria.
About 20 years ago, researchers in the laboratory of MIT biology professor Anthony Sinskey started swapping genes between different bacteria, hoping to achieve industrial production of desirable natural compounds synthesized by those bacteria.
The researchers focused their "biopolymer engineering" efforts on a group of genes that code for enzymes in a pathway that produces polyesters. Those polyesters can be broken down into metabolites naturally produced by humans, so they cause no harm when absorbed.
Once the genes were identified, they could be transferred into a strain of industrial E. coli that can produce large quantities of the strong, flexible polymer.
The FDA cleared the biopolymer sutures on Feb. 8, and Williams said Tepha plans to start marketing them soon, in partnership with another company.
"Not only is it technically and in an engineering sense a tremendous victory, but it's also a victory for society because this leads to new medical devices that can help people in new and novel ways," said Sinskey, who is one of the founders of Tepha and sits on its board of directors.
The new suture is the first of what the researchers hope will be many medical devices made from the natural polyesters.
"What we've found is that this one material seems to be finding a lot of use in different applications," because of its wide range of desirable properties, Williams said.Tepha is now working on developing other medical devices, such as surgical meshes, multifilament fibers and stents. Ultimately, the researchers hope to develop an artificial scaffold that could be used to grow heart valves after being implanted in a patient, which would spare children with heart valve defects from undergoing repeated surgeries.
Tests of the device in animals have shown promise.
"We've been able to show we can produce a valve scaffold that functions better and can grow with the animal," Williams said. "If the valve can grow with the patient, you don't need the repeated surgeries."
Tepha, founded six years ago, is a spinoff of Metabolix, a company the researchers founded in 1992 to market bioplastics and biopolymer packaging materials.
Other current and former MIT researchers who helped develop the recombinant DNA methods used to create the biopolymer are JoAnne Stubbe, Novartis Professor of Chemistry and professor of biology, former postdoctoral associate Oliver Peoples and the late Professor Emeritus Satoru Masamune.
Original work at MIT on this technique was funded by the National Institutes of Health.
Elizabeth Thomson | EurekAlert!
Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern
20.07.2018 | Princeton University
Relax, just break it
20.07.2018 | DOE/Argonne National Laboratory
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
20.07.2018 | Power and Electrical Engineering
20.07.2018 | Information Technology
20.07.2018 | Materials Sciences