A peptide called magainin, first found in the skin of the African clawed frog, holds the secret to creating bacteria-killing surfaces, according to researchers at the University of Pennsylvania. The Penn scientists have taken a joint experimental-computational approach to mimicking magainin. They designed, synthesized, tested, and then improved novel antibacterial compounds, using a combination of laboratory experiments and painstaking simulations on supercomputers. The resulting material could be anchored to the surface of almost any type of product that you would prefer to keep bacteria-free – from bandages to picnic tables.
Robert Doerksen, a postdoctoral researcher in Penns Department of Chemistry, will present how the Penn team successfully modified the arylamide-based polymers to be safe for contact with human cells today at the American Chemical Societys 227th National Meeting in Anaheim, Calif.
"Our original approach was to replace the peptide backbone found in magainin with one of arylamide, which is relatively easy to create in the lab," Doerksen said. "Like magainin, the modified arylamide polymer can disrupt the cell membranes of bacteria without harming the membranes of other types of cells, such as our own."
Greg Lester | EurekAlert!
A new paradigm of material identification based on graph theory
17.06.2019 | Science China Press
Electron beam strengthens recyclable nanocomposite
17.06.2019 | Kanazawa University
The well-known representation of chemical elements is just one example of how objects can be arranged and classified
The periodic table of elements that most chemistry books depict is only one special case. This tabular overview of the chemical elements, which goes back to...
Light can be used not only to measure materials’ properties, but also to change them. Especially interesting are those cases in which the function of a material can be modified, such as its ability to conduct electricity or to store information in its magnetic state. A team led by Andrea Cavalleri from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg used terahertz frequency light pulses to transform a non-ferroelectric material into a ferroelectric one.
Ferroelectricity is a state in which the constituent lattice “looks” in one specific direction, forming a macroscopic electrical polarisation. The ability to...
Researchers at TU Graz calculate the most accurate gravity field determination of the Earth using 1.16 billion satellite measurements. This yields valuable knowledge for climate research.
The Earth’s gravity fluctuates from place to place. Geodesists use this phenomenon to observe geodynamic and climatological processes. Using...
Discovery by Brazilian and US researchers could change the classification of two species, which appear more akin to jellyfish than was thought.
The tube anemone Isarachnanthus nocturnus is only 15 cm long but has the largest mitochondrial genome of any animal sequenced to date, with 80,923 base pairs....
Researchers at Chalmers University of Technology, Sweden, have discovered a completely new way of capturing, amplifying and linking light to matter at the nanolevel. Using a tiny box, built from stacked atomically thin material, they have succeeded in creating a type of feedback loop in which light and matter become one. The discovery, which was recently published in Nature Nanotechnology, opens up new possibilities in the world of nanophotonics.
Photonics is concerned with various means of using light. Fibre-optic communication is an example of photonics, as is the technology behind photodetectors and...
29.04.2019 | Event News
17.04.2019 | Event News
15.04.2019 | Event News
17.06.2019 | Information Technology
17.06.2019 | Earth Sciences
17.06.2019 | Ecology, The Environment and Conservation