A new 'microcapsule' treatment delivery method developed by researchers at Queen Mary University of London (QMUL) could reduce inflammation in cartilage affected by osteoarthritis and reverse damage to tissue. The research was funded by Arthritis Research UK and the AO Foundation.
A protein molecule called C-type natriuretic peptide (CNP), which occurs naturally in the body, is known to reduce inflammation and aid in the repair of damaged tissue. However, CNP cannot be used to treat osteoarthritis in patients because it cannot target the damaged area even when the protein is injected into the cartilage tissue. This is because CNP is easily broken down and cannot reach the diseased site.
The researchers constructed tiny microcapsules, just 2 microns in diameter, with individual layers containing CNP that could release the protein slowly and therefore deliver the treatment in the most effective way.
In experiments on samples of cartilage taken from animals, they showed that the microcapsules could deliver the anti-inflammatory CNP in a highly effective way. The researchers believe that injections of microcapsules could in the future be used to heal damaged cartilage in people with osteoarthritis. The injections could be delivered easily by a GP.
Dr Tina Chowdhury from QMUL's School of Engineering and Materials Science, who leads the research, said:
"If this method can be transferred to patients it could drastically slow the progression of osteoarthritis and even begin to repair damaged tissue.
"CNP is currently available to treat other conditions such as skeletal diseases and cardiovascular repair. If we could design simple injections using the microcapsules, this means the technology has the potential to be an effective and relatively cheap treatment that could be delivered in the clinic or at home."
Dr Stephen Simpson, Director of Research at Arthritis Research UK said:
"Current treatment options for osteoarthritis are limited, and therefore developing new ways to treat this painful and debilitating condition is currently a major area of research. The focus is not only about identifying promising new targets, as delivery of a drug to the appropriate site can often be as challenging as developing the treatment itself, and can hinder getting otherwise effective medicines to patients. This work represents a good example of how researchers are developing innovative new approaches to get around this problem."
Will Hoyles | EurekAlert!
Research finds new molecular structures in boron-based nanoclusters
13.07.2018 | Brown University
3D-Printing: Support structures to prevent vibrations in post-processing of thin-walled parts
12.07.2018 | Fraunhofer-Institut für Produktionstechnologie IPT
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
16.07.2018 | Physics and Astronomy
16.07.2018 | Transportation and Logistics
16.07.2018 | Agricultural and Forestry Science