This advance, published online in the journal Advanced Materials, allows the production of tissue culture scaffolds containing multiple structurally and chemically distinct layers using common laboratory reagents and materials.
According to the UC San Diego researchers, this process is more affordable and widely feasible than previous methods that required expensive equipment and expertise.
The new approach is remarkably simple: solutions of the components of each layer, including polymers, are mixed with varying concentrations of a common inert reagent to control density. The solutions are layered so that the difference in density segregates each solution, and then polymerized so that they form a gel. The structure of each layer can be altered by varying the concentration of polymers, and the discreteness of the transition between layers can be altered by allowing the solutions to diffuse.
Lead author Jerome Karpiak, graduate student in the UCSD Biomedical Sciences Program, said, "We're excited about the relevance of this method to tissue engineering. Since it offers such straightforward spatial control over structure and composition of stratified tissue scaffolds, including cell type and density, this technology could help the field move much faster." Tissues cultured in vitro to mimic those in the body can potentially provide an alternative to transplantation for injured or degenerated tissue.
"We believe this approach will vastly broaden the number of labs capable of culturing complex tissue," said Adah Almutairi, PhD, assistant professor at the UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, the Department of Nanoengineering and the Materials Science and Engineering Program at the UCSD Jacobs School of Engineering. "Because manipulation of structure and concentrations of signal molecules is much easier in this system than in intact organisms, it holds great potential to advance the study of development and disease." For example, this method may offer a novel approach to study how surrounding molecules affect the growth of axons in neurodevelopmental disorders.
Additional researchers included Yogesh Ner, PhD. Research was funded in part by the National Institutes of Health Director's New Innovator program and King Abdulaziz City of Science and Technology.
Debra Kain | EurekAlert!
Oriented hexagonal boron nitride foster new type of information carrier
25.05.2020 | Japan Advanced Institute of Science and Technology
A replaceable, more efficient filter for N95 masks
22.05.2020 | American Chemical Society
In living cells, enzymes drive biochemical metabolic processes enabling reactions to take place efficiently. It is this very ability which allows them to be used as catalysts in biotechnology, for example to create chemical products such as pharmaceutics. Researchers now identified an enzyme that, when illuminated with blue light, becomes catalytically active and initiates a reaction that was previously unknown in enzymatics. The study was published in "Nature Communications".
Enzymes: they are the central drivers for biochemical metabolic processes in every living cell, enabling reactions to take place efficiently. It is this very...
Early detection of tumors is extremely important in treating cancer. A new technique developed by researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from normal tissue. The work is published May 25 in the journal Nature Nanotechnology.
researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from...
Microelectronics as a key technology enables numerous innovations in the field of intelligent medical technology. The Fraunhofer Institute for Biomedical Engineering IBMT coordinates the BMBF cooperative project "I-call" realizing the first electronic system for ultrasound-based, safe and interference-resistant data transmission between implants in the human body.
When microelectronic systems are used for medical applications, they have to meet high requirements in terms of biocompatibility, reliability, energy...
Thomas Heine, Professor of Theoretical Chemistry at TU Dresden, together with his team, first predicted a topological 2D polymer in 2019. Only one year later, an international team led by Italian researchers was able to synthesize these materials and experimentally prove their topological properties. For the renowned journal Nature Materials, this was the occasion to invite Thomas Heine to a News and Views article, which was published this week. Under the title "Making 2D Topological Polymers a reality" Prof. Heine describes how his theory became a reality.
Ultrathin materials are extremely interesting as building blocks for next generation nano electronic devices, as it is much easier to make circuits and other...
Scientists took a leukocyte as the blueprint and developed a microrobot that has the size, shape and moving capabilities of a white blood cell. Simulating a blood vessel in a laboratory setting, they succeeded in magnetically navigating the ball-shaped microroller through this dynamic and dense environment. The drug-delivery vehicle withstood the simulated blood flow, pushing the developments in targeted drug delivery a step further: inside the body, there is no better access route to all tissues and organs than the circulatory system. A robot that could actually travel through this finely woven web would revolutionize the minimally-invasive treatment of illnesses.
A team of scientists from the Max Planck Institute for Intelligent Systems (MPI-IS) in Stuttgart invented a tiny microrobot that resembles a white blood cell...
19.05.2020 | Event News
07.04.2020 | Event News
06.04.2020 | Event News
27.05.2020 | Information Technology
27.05.2020 | Physics and Astronomy
27.05.2020 | Earth Sciences