Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Giving cells star treatment

15.06.2015

A three-dimensional star-shaped polymer network enhances cell adhesion and growth for tissue regeneration.

Tissues and organs in the body are sometimes damaged to such an extent that they require artificial support to heal. Now, A*STAR researchers have used star-shaped polymers to produce a three-dimensional network that is both compatible with human tissue and facilitates cells to adhere and proliferate under controlled biological conditions[¹].


Schematic representation of the star-shaped polymer network showing the polyhedral oligomeric silsesquioxane (POSS) cores and crosslinked polycaprolactone (PCL)–polyurethane (PU) arms.

Copyright : Adapted by A*STAR with permission from Macmillan Publishers Ltd: NPG Asia Materials (Ref. 1), copyright (2014)

To build this network, Ming-Yong Han, Khin Yin Win and co-workers from the A*STAR Institute of Materials Research and Engineering in Singapore incorporated an inorganic component ― polyhedral oligomeric silsesquioxane (POSS) ― into a common tissue engineering material, polycaprolactone–polyurethane.

This addition was designed to enhance the material’s porosity and interaction with cells as well as improve its thermal and mechanical stability. POSS consisted of a silica cube bearing eight organic arms capable of covalent bonding with other polymers (see image). The silica cube provided a rigid core from which emerged polycaprolactone–polyurethane arms.

To generate this material, the researchers synthesized POSS cores terminated by reactive functional groups from an organic alcohol, in the presence of a silicon-based catalyst. They then attached polycaprolactone units to the cores to extend their arms. Finally, they added the polyurethane precursor as a crosslinker to complete the network.

Unlike its linear counterpart, the POSS-based material had a rough surface consisting of microscopic spheres from which fibrous structures spread. The unique surface morphology, which consisted of water-repelling POSS and polymer arms, helped the cells to adhere and proliferate. This biomaterial was biocompatible and had a high porosity; these properties allowed the material to promote cell growth while simultaneously permitting the exchange of nutrients and metabolites.

The researchers evaluated the degradation of the polymer network under physiological conditions for 52 weeks. The network decomposed little during the first 24 weeks, but subsequently lost weight rapidly.

Han explains that the water-repelling nature and protective effect of the POSS moieties limited the initial hydrolytic degradation. “The degradation accelerated only after these POSS moieties had broken down,” he adds.

This degradation behavior enables cell adhesion and proliferation on the network during the initial stage and elimination of the scaffold after tissue has formed, making the POSS-based network highly attractive as a scaffold. Moreover, most cells remained viable when exposed to the degradation products of these POSS-based and linear polymers, confirming their biocompatibility.

The team is currently exploring ways to apply the star-shaped polymer as a scaffold for tissue regeneration. “We are planning to use it for three-dimensional tissue reconstruction and modeling,” says Han.

The A*STAR-affiliated researchers contributing to this research are from the Institute of Materials Research and Engineering.

Reference

1. Teng, C. P., Mya, K. Y., Win, K. Y., Yeo, C. C., Low, M., He, C. & Han, M.-Y. Star-shaped polyhedral oligomeric silsesquioxane-polycaprolactone-polyurethane as biomaterials for tissue engineering application. NPG Asia Materials 6, e142 (2014). |


Associated links
http://www.research.a-star.edu.sg/research/7294
 

A*STAR Research | ResearchSEA
Further information:
http://www.researchsea.com

More articles from Materials Sciences:

nachricht Machine-learning predicted a superhard and high-energy-density tungsten nitride
18.07.2018 | Science China Press

nachricht In borophene, boundaries are no barrier
17.07.2018 | Rice University

All articles from Materials Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

NYSCF researchers develop novel bioengineering technique for personalized bone grafts

18.07.2018 | Life Sciences

Machine-learning predicted a superhard and high-energy-density tungsten nitride

18.07.2018 | Materials Sciences

Why might reading make myopic?

18.07.2018 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>