Brighter future for carbon dots
Work led by Amita Pathak at the Indian Institute of Technology has produced water-soluble C-dots that selectively emit light across the entire visible range without any surface coating. The properties of these new C-dots make them ideal for a variety of bioimaging applications and for medical diagnostics.
Carbon dots (C-dots) are light-emitting (luminescent) nanoparticles that can be used to track biological processes inside cells. They are less toxic than similar alternatives, making them more suitable for use in live biological systems, but the light-emitting properties of those currently made are not ideal.
A variety of approaches have been used to make C-dots, but most require coating of the particles with other molecules to achieve useful luminescence. Now, work led by Amita Pathak at the Indian Institute of Technology has produced water-soluble C-dots that selectively emit light across the entire visible range without any surface coating.
The researchers produced these C-dots by breaking down the carbohydrate dextrin with microwaves. The resulting C-dots emitted different colours of light when excited by specific wavelengths, even without coating them. Exactly how this multi-coloured luminescence arises is unclear, but it allows precise control of the light emission that can be tailored to specific needs.
To ensure that the C-dots were not toxic, the team added different concentrations of the nanoparticles to cultured cells. After three days, they determined how many cells had survived. Increasing concentrations of C-dots made little difference to cell survival, showing that the C-dots are not toxic and could therefore be used in live tissue.
The properties of these new C-dots make them ideal for a variety of bioimaging applications and for medical diagnostics. The same researchers have already begun to look at how they may be used to investigate interactions between drugs and cells.
Nagaprasad Puvvada, B N Prashanth Kumar, Suraj Konar, Himani Kalita, Mahitosh Mandal and Amita Pathak (2012) “Synthesis of biocompatible multicolor luminescent carbon dots for bioimaging applications” Sci. Technol. Adv. Mater. Vol. 13 p. 045008
National Institute for Materials Science
Mikiko Tanifuji | Research asia research news
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
What does it look like below the ice shelf of the calved massive iceberg A68?
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...