A polymer inspired by the lipids in cell membranes is proving an invaluable biomaterial. Like the cell membrane, the polymer 2-methacryloyloxyethyl phosphorylcholine (MPC) can provide a surface for biological reactions to take place, but it can also suppress unfavourable processes.
In their recently published review article, Yasuhiko Iwasaki at Kansai University and Kazuhiko Ishihara at the University of Tokyo in Japan describe how developments in synthesis techniques by showing that the 2-methacryloyloxyethyl phosphorylcholine (MPC) have liberated the polymer’s potential for a huge range of medical and biological applications.
In fact the polymers were already attracting interest in the early 1970s. However until more facile synthesis techniques were developed investigations were limited and the polymer was little understood. By 1999 MPC polymers were being produced on an industrial scale, allowing more substantial studies. MPC is easily polymerized in a range of architectures. The chemical can suppress reactions such as protein adsorption and cell adhesion and has a high and readily adjustable solubility in water. These versatile properties lend MPC polymers to a range of applications.
The authors also describe methods for generating the polymer for effective use in non-fouling coatings. Formed into poly(MPC) brush structures with specified chain architectures, they can also be used as surfaces for controlling cell functions. In addition, the researchers explain how surface modifications with MPC polymers are effective in improving blood compatibility. The polymers can suppress protein adsorption, platelet adhesion, and platelet activation at blood-contacting surfaces and they can also be solute permeable. As such they are well suited for coating cardiovascular applications such as stents, cardiopulmonary bypasses, and ventricular assist devices.
Based on the fact that “MPC and various kinds of MPC polymers are now available commercially worldwide, and many medical devices treated with MPC polymers are used in clinics,” they underline how far research into applications of MPC has advanced, and indicate how many possibilities remain for exploiting the chemical further.Media contacts:
*E-mail address: firstname.lastname@example.org. Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
*E-mail address: email@example.com
Mikiko Tanifuji | Research asia research news
Brilliant glow of paint-on semiconductors comes from ornate quantum physics
17.01.2019 | Georgia Institute of Technology
Viennese scientists develop promising new type of polymers
15.01.2019 | Vienna University of Technology
World first experiments on sensor that may revolutionise everything from medical devices to unmanned vehicles
The new sensor - capable of detecting vibrations of living cells - may revolutionise everything from medical devices to unmanned vehicles.
Dead and alive at the same time? Researchers at the Max Planck Institute of Quantum Optics have implemented Erwin Schrödinger’s paradoxical gedanken experiment employing an entangled atom-light state.
In 1935 Erwin Schrödinger formulated a thought experiment designed to capture the paradoxical nature of quantum physics. The crucial element of this gedanken...
Cellulose obtained from wood has amazing material properties. Empa researchers are now equipping the biodegradable material with additional functionalities to produce implants for cartilage diseases using 3D printing.
It all starts with an ear. Empa researcher Michael Hausmann removes the object shaped like a human ear from the 3D printer and explains:
The phenomenon of so-called superlubricity is known, but so far the explanation at the atomic level has been missing: for example, how does extremely low friction occur in bearings? Researchers from the Fraunhofer Institutes IWM and IWS jointly deciphered a universal mechanism of superlubricity for certain diamond-like carbon layers in combination with organic lubricants. Based on this knowledge, it is now possible to formulate design rules for supra lubricating layer-lubricant combinations. The results are presented in an article in Nature Communications, volume 10.
One of the most important prerequisites for sustainable and environmentally friendly mobility is minimizing friction. Research and industry have been dedicated...
Just in time for Christmas, a Mars-analogue mission in Morocco, coordinated by the Robotics Innovation Center of the German Research Center for Artificial Intelligence (DFKI) as part of the SRC project FACILITATORS, has been successfully completed. SRC, the Strategic Research Cluster on Space Robotics Technologies, is a program of the European Union to support research and development in space technologies. From mid-November to mid-December 2018, a team of more than 30 scientists from 11 countries tested technologies for future exploration of Mars and Moon in the desert of the Maghreb state.
Close to the border with Algeria, the Erfoud region in Morocco – known to tourists for its impressive sand dunes – offered ideal conditions for the four-week...
16.01.2019 | Event News
14.01.2019 | Event News
12.12.2018 | Event News
17.01.2019 | Physics and Astronomy
17.01.2019 | Materials Sciences
17.01.2019 | Information Technology