Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New ways to detect and treat Alzheimer's disease

17.11.2010
Specific brain changes suggest new diagnostic markers and therapeutic targets

New studies identify brain changes in people with Alzheimer's disease. The results give researchers a greater understanding of the disease and may help at-risk individuals by improving early detection.

New animal research also shows a novel approach to Alzheimer's vaccine design that may avoid dangerous side effects. These new results were reported at Neuroscience 2010, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news on brain science and health.

About 5.3 million people have Alzheimer's disease, according to the Alzheimer's Association. With the aging baby boomer population, Alzheimer's will continue to affect more people worldwide. Better diagnostic techniques may help identify the disease at earlier, potentially more treatable stages.

Today's new findings show that:

People with Alzheimer's disease show structural changes in the caudate nucleus, a brain structure typically associated with movement disorders such as Parkinson's disease, suggesting that the disease produces broader damage in the brain than previously thought (Sarah Madsen, abstract 348.4, see attached summary).

People at risk for Alzheimer's disease exhibit a structural change in portions of the cerebral cortex, which is largely responsible for reasoning, memory and other "higher function" tasks. The findings may help identify those who would most benefit from early intervention (Sarah George, abstract 756.9, see attached summary).

A new vaccine, which was tested in mice, could protect against memory problems associated with Alzheimer's disease without potentially dangerous side effects. The vaccine targeted a non-human protein that may make it a safer alternative to previous vaccine approaches that caused inflammation in human clinical trials (Charles Glabe, PhD, abstract 725.6, see attached summary).

Too many small aggregates of a protein called tau in the brain can directly interfere with memory, according to new animal research. The findings are important because they suggest that tau may be a good target for developing therapies against Alzheimer's and related diseases (Ottavio Arancio, MD, PhD, abstract 527.8, see attached summary).

"Identifying those at risk for Alzheimer's and developing new treatments for nervous system disorders is a social imperative," said press conference moderator Sam Sisodia, PhD, of the University of Chicago, an expert on the cellular biology of proteins implicated in Alzheimer's disease. "These studies are evidence that we're making real progress to overcome this tragic epidemic."

This research was supported by national funding agencies, such as the National Institutes of Health, as well as private and philanthropic organizations.

Kat Snodgrass | EurekAlert!
Further information:
http://www.sfn.org

More articles from Studies and Analyses:

nachricht Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern

nachricht Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>