Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Viruses thrive in big families, in sickness and in health

05.08.2015

Study suggests that big families have viral infections for 87 percent of the year. But only half cause illness.

The BIG LoVE (Utah Better Identification of Germs-Longitudinal Viral Epidemiology) study, led by scientists at the University of Utah School of Medicine, finds that each bundle of joy puts the entire household at increased risk for infection with viruses that cause colds, flu, and other respiratory illnesses.


The BIG-LoVE (Utah Better Identification of Germs-Longitudinal Viral Epidemiology) study by investigators at the University of Utah School of Medicine shows that every child increases the risk that a household will be infected with respiratory virus. At one extreme, childless households are only sick for 7 percent of the year (3-4 weeks). By contrast, families with 6 children are sick for 87 percent of the year (45 weeks).

Credit: University of Utah School of Medicine

People living in childless households were infected with viruses on average 3-4 weeks during the year. In households with one child, that number jumped to 18 weeks, and for those with six children, there was virus in the household for up to 45 weeks out of the year.

Yet on average only half of those who tested positive for viral infection also had the typical symptoms of coughing, fever, and stuffy nose, an informative finding for both families and their health care providers. The results were published in the journal, Clinical Infectious Diseases.

Kids Fill Hearts With Love, And Homes With Illness

When it comes to explaining why big families have more illnesses, all signs point to young kids as the culprits. Tots younger than five had at least one virus detected in their nasal mucus for 50 percent of the year: twice as often as older children and adults. And when infected, they were 1.5 times more likely to have symptoms, including severe ones like wheezing and fever.

Adding even more stress to a household, young kids didn't suffer alone. Their parents were sick 1.5 times more frequently than similarly aged adults who did not live with young kids.

"A lot families go through wave after wave of illness. In fact, some of the kids we monitored had symptoms for 20 to 25 weeks in a row," says co-first author Carrie Byington, M.D., professor of pediatrics and co-director of the Utah Center for Clinical and Translational Science. "This study helps us to understand what is normal in young children, and can help us determine when illness should be a cause for concern."

It's no secret that children get sick a lot. But BIG LoVE - a year-long survey of a Utah community - is one of the first to use modern diagnostics to track how often kids and other family members, both sick and well, have nasal infections of respiratory virus. Future studies will determine if reported trends hold true in larger and diverse populations.

A Positive Test May Not Mean Positively Sick

Perhaps the most surprising finding was how often participants carried virus, and showed no signs of being sick.

PCR-based diagnostics, like those used to test participants' samples in this study, are becoming increasingly common in clinical settings because they are much more sensitive and accurate than older tests, and provide results within hours, not days. Yet these findings suggest that some test results should be interpreted with caution.

While study participants infected with influenza and parainfluenza viruses were sick most of the time, those who carried rhinovirus - the cause of the common cold - were only sick half of the time.

What's more, results suggest that even after a patient recovers from an illness, some viruses persist for weeks afterward. Bocavirus persisted in the nose for as long as 12 weeks, but more commonly viruses persisted for two weeks or less. In an accompanying commentary also published in Clinical Infectious Diseases, Gregory A. Storch, M.D., of Washington University School of Medicine in St. Louis, noted that the research "provides highly useful information," especially concerning how long PCR-based tests remained positive during each viral episode.

If presence of virus doesn't always translate into illness, then it stands to reason that even if someone is sick and tests positive for a specific virus, there could be another cause. For example bacteria, or a rare virus not detected by the test. Health care providers should be aware of these limitations.

"If a child comes into the emergency room with severe respiratory illness and tests positive for rhinovirus, it might be a smart idea for doctors to make sure they're not missing something else that could be the cause," says co-first author and professor of pediatrics Krow Ampofo, M.B., Ch.B.

How Sickness Was Studied

BIG LoVE was a project to investigate how viruses are transmitted in families. Monitoring a community in Utah, the state with the largest number of children per household, allowed investigators to track differences among big and small families.

Investigators monitored 26 households collectively made up of 108 individuals (three were born during the course of the study) for one year. Each household collected nasal swabs from family members once per week and documented when they had symptoms typical of cold and flu. A PCR-based test, the FilmArray by BioFire Diagnostics, probed swabs for 16 different respiratory viruses, including influenza, rhinovirus, and respiratory syncytial virus (RSV). 4166 samples were analyzed in all. Future studies will examine trends in larger communities, and those in other geographical regions, and of different ethnicities.

###

"Community Surveillance of Respiratory Viruses among Families in the Utah Better Identification of Germs-Longitudinal Viral Epidemiology (BIG-LoVE) Study" was published online in Clinical Infectious Diseases online on August 5, 2015

The work was supported by the National Institutes of Health (NIH), The HA and Edna Benning Presidential Endowment, The Primary Children's Hospital Foundation, the Pediatric Clinical and Translational Scholars Program, and the James S. McDonnell Foundation

In addition to Byington and Ampofo, the authors included Chris Stockmann, MSc, Frederick R. Adler, Ph.D., Amy Herbener, M.D., , Xiaoming Sheng, Ph.D., Anne J. Blaschke, M.D., Ph.D., and Andrew T. Pavia, M.D. from the University of Utah, and Trent Miller and Robert Crisp, Ph.D. from BioFire Diagnostics

CB, AJB, KA, XS, and ATP are investigators on NIH-funded studies in collaboration with BioFire Diagnostics. CB and AJB have intellectual property in and receive royalties from BioFire Diagnostics. ATP has served as a consultant for BioFire Diagnostics. TM and RC were employees of BioFire Diagnostics during the study period.

Julie Kiefer | EurekAlert!

More articles from Studies and Analyses:

nachricht TU Dresden biologists examine sperm quality on the basis of their metabolism
29.11.2019 | Technische Universität Dresden

nachricht Approaching the perception of touch in the brain
27.11.2019 | Max Planck Institute for Human Cognitive and Brain Sciences

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Highly charged ion paves the way towards new physics

In a joint experimental and theoretical work performed at the Heidelberg Max Planck Institute for Nuclear Physics, an international team of physicists detected for the first time an orbital crossing in the highly charged ion Pr⁹⁺. Optical spectra were recorded employing an electron beam ion trap and analysed with the aid of atomic structure calculations. A proposed nHz-wide transition has been identified and its energy was determined with high precision. Theory predicts a very high sensitivity to new physics and extremely low susceptibility to external perturbations for this “clock line” making it a unique candidate for proposed precision studies.

Laser spectroscopy of neutral atoms and singly charged ions has reached astonishing precision by merit of a chain of technological advances during the past...

Im Focus: Ultrafast stimulated emission microscopy of single nanocrystals in Science

The ability to investigate the dynamics of single particle at the nano-scale and femtosecond level remained an unfathomed dream for years. It was not until the dawn of the 21st century that nanotechnology and femtoscience gradually merged together and the first ultrafast microscopy of individual quantum dots (QDs) and molecules was accomplished.

Ultrafast microscopy studies entirely rely on detecting nanoparticles or single molecules with luminescence techniques, which require efficient emitters to...

Im Focus: How to induce magnetism in graphene

Graphene, a two-dimensional structure made of carbon, is a material with excellent mechanical, electronic and optical properties. However, it did not seem suitable for magnetic applications. Together with international partners, Empa researchers have now succeeded in synthesizing a unique nanographene predicted in the 1970s, which conclusively demonstrates that carbon in very specific forms has magnetic properties that could permit future spintronic applications. The results have just been published in the renowned journal Nature Nanotechnology.

Depending on the shape and orientation of their edges, graphene nanostructures (also known as nanographenes) can have very different properties – for example,...

Im Focus: Electronic map reveals 'rules of the road' in superconductor

Band structure map exposes iron selenide's enigmatic electronic signature

Using a clever technique that causes unruly crystals of iron selenide to snap into alignment, Rice University physicists have drawn a detailed map that reveals...

Im Focus: Developing a digital twin

University of Texas and MIT researchers create virtual UAVs that can predict vehicle health, enable autonomous decision-making

In the not too distant future, we can expect to see our skies filled with unmanned aerial vehicles (UAVs) delivering packages, maybe even people, from location...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

The Future of Work

03.12.2019 | Event News

First International Conference on Agrophotovoltaics in August 2020

15.11.2019 | Event News

Laser Symposium on Electromobility in Aachen: trends for the mobility revolution

15.11.2019 | Event News

 
Latest News

Self-driving microrobots

11.12.2019 | Materials Sciences

Innovation boost for “learning factory”: European research project “SemI40” generates path-breaking findings

11.12.2019 | Information Technology

Molecular milk mayonnaise: How mouthfeel and microscopic properties are related in mayonnaise

11.12.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>