Older veterans who have experienced a traumatic brain injury (TBI) are 60 percent more likely to later develop dementia than veterans without TBI, according to a study published in the June 25, 2014, online issue of Neurology®, the medical journal of the American Academy of Neurology.
The study also found that veterans with a history of TBI developed dementia about two years earlier than those without TBI who had developed dementia.
“These findings suggest that a history of TBI contributes risk for dementia in later life in veterans. If we assume that this relationship is causal, it seems likely that the same increased risk probably occurs with TBI in the civilian population as well,” said study author Deborah E. Barnes, PhD, MPH, of the University of California, San Francisco and the San Francisco Veterans Affairs Medical Center and a member of the American Academy of Neurology.
The study involved 188,784 veterans with an average age of 68 at the start of the study. All were free of dementia at the start of the study and had at least one visit to a VA health care facility at the start of the study and again an average of seven years later.
A total of 1,229 of the veterans had a TBI diagnosis. During the follow-up period, 196 veterans with TBI, or 16 percent, developed dementia, compared to 18,255, or 10 percent of those without TBI. After adjusting for other factors that could affect the risk of dementia, such as diabetes, high blood pressure, depression and alcohol abuse, researchers determined that veterans with TBI were 60 percent more likely to develop dementia than those without TBI.
On average, veterans with TBI developed dementia two years earlier than those without TBI, or at age 78.5 compared to 80.7. Also, those who did not develop dementia died 2.3 years earlier if they had a TBI versus no TBI (77.0 years versus 79.3 years). The researchers also found that the risk of dementia was higher in veterans with TBI who also had depression, post-traumatic stress disorder or cerebrovascular disease than in those with either TBI or these other conditions alone.
“This study convincingly shows that mild trauma has a role in increasing the risk of dementia and sheds light on the more complex relationship between medical and psychiatric diseases with TBI in the development of the future risk of dementias. Neuroscientists must take a careful and comprehensive approach and avoid oversimplified claims of causality,” said Rodolfo Savica, MD, MSc, of the University of Utah School of Medicine in Salt Lake City, and a member of the American Academy of Neurology, who wrote an editorial accompanying the study.
The study was supported by the U.S. Department of Defense/NCIRE and the National Institutes of Health.
To learn more about traumatic brain injury and dementia, please visit www.aan.com/patients.
The American Academy of Neurology, an association of more than 28,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson’s disease and epilepsy.
Rachel L. Seroka
Manager, Media and Public Relations
American Academy of Neurology
201 Chicago Avenue
Minneapolis, MN 55415
Ph: 612-928-6129 Mobile: 612-807-6968 Fax: 612-454-2744
Rachel L. Seroka | American Academy of Neurology
Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel
Oxygen loss in the coastal Baltic Sea is “unprecedentedly severe”
05.07.2018 | European Geosciences Union
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
13.07.2018 | Event News
13.07.2018 | Materials Sciences
13.07.2018 | Life Sciences