Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the results provide confidence in the efficacy of breast-conserving treatments even among patients with aggressive, early disease.
Lumpectomy combined with radiation is a good treatment choice for women with early breast cancer; however, over the past 10 years, a growing number of women have been choosing mastectomy even for very small cancers. In certain populations—such as women who are young and those living in urban areas with high socioeconomic status—this trend has been most pronounced due to the perception that outcomes may be better with mastectomy than with lumpectomy.
Shelley Hwang MD, MPH, of the Duke Cancer Institute, and her colleagues looked to see whether some populations of women do in fact have better outcomes after mastectomy compared with lumpectomy and radiation. The researchers obtained information regarding all women who were diagnosed in the state of California with stage I or II breast cancer between 1990 and 2004 and who were treated with either mastectomy or lumpectomy plus radiation. The investigators followed 112,154 cases through 2009, and they looked for patterns among different age groups and across different breast cancer types.
In the first three years after surgery, women who underwent mastectomy had a higher risk of dying from heart disease and other diseases than women who underwent lumpectomy, possibly indicating that the latter group was generally healthier, according to Dr. Hwang. Over the entire study period, women were more likely to survive breast cancer after undergoing lumpectomy plus radiation than mastectomy. This was true among all age groups and cancer types, with the biggest benefit seen in women over 50 years of age with hormone-sensitive breast cancer. These women had a 14 percent decreased risk of dying from breast cancer during the study compared with their counterparts who underwent mastectomy.
"The findings in this study should reassure women that among all age groups and tumor types, lumpectomy continues to be an excellent choice for women with small early breast cancers," said Dr. Hwang.
Amy Molnar | EurekAlert!
New study first to predict which oil and gas wells are leaking methane
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Cellulose obtained from wood has amazing material properties. Empa researchers are now equipping the biodegradable material with additional functionalities to produce implants for cartilage diseases using 3D printing.
It all starts with an ear. Empa researcher Michael Hausmann removes the object shaped like a human ear from the 3D printer and explains:
The phenomenon of so-called superlubricity is known, but so far the explanation at the atomic level has been missing: for example, how does extremely low friction occur in bearings? Researchers from the Fraunhofer Institutes IWM and IWS jointly deciphered a universal mechanism of superlubricity for certain diamond-like carbon layers in combination with organic lubricants. Based on this knowledge, it is now possible to formulate design rules for supra lubricating layer-lubricant combinations. The results are presented in an article in Nature Communications, volume 10.
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Just in time for Christmas, a Mars-analogue mission in Morocco, coordinated by the Robotics Innovation Center of the German Research Center for Artificial Intelligence (DFKI) as part of the SRC project FACILITATORS, has been successfully completed. SRC, the Strategic Research Cluster on Space Robotics Technologies, is a program of the European Union to support research and development in space technologies. From mid-November to mid-December 2018, a team of more than 30 scientists from 11 countries tested technologies for future exploration of Mars and Moon in the desert of the Maghreb state.
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Research opens doors in photonic quantum information processing, optical signal processing and microwave photonics
Researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed a new integrated photonics platform that can...
A team of experimentalists at the U.S. Department of Energy's Ames Laboratory and theoreticians at University of Alabama Birmingham discovered a remarkably long-lived new state of matter in an iron pnictide superconductor, which reveals a laser-induced formation of collective behaviors that compete with superconductivity.
"Superconductivity is a strange state of matter, in which the pairing of electrons makes them move faster," said Jigang Wang, Ames Laboratory physicist and...
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