Led by Dr. Amit Garg, a researcher at Lawson Health Research Institute and nephrologist at London Health Sciences Centre, the results provide important safety reassurances to donors, their recipients and health care professionals. In the general population, there is a strong link between reduced kidney function and an increased risk of heart disease. Previous studies suggest no evidence of a higher risk for living kidney donors, however, a consensus among health care providers had not been reached.
Dr. Garg's study involved 2,028 Ontarians who donated a kidney between 1992 and 2009, and 2,0280 healthy non-donors for comparison. "We manually reviewed the medical charts of over 2000 living kidney donors in Ontario and linked this information to universal healthcare databases to reliably follow major cardiovascular events," says Dr. Garg.
Despite reduced kidney function in the donors, the researchers found that donors had a lower risk of death and heart disease compared to non-donors. Dr. Garg is the kidney specialist who evaluates all individuals in Southwestern Ontario who are interested in becoming a kidney donor. According to Dr. Garg, potential donors must pass a rigorous approval process to be considered for living kidney donation, and in such, only the healthiest people are considered.
There has been a trend towards relaxing the selection criteria in order to help with Canada's organ donation shortage. However, Dr. Garg says this study does not inform such changes in the selection process; the long-term outcomes of these new types of donors needs further study.
According to an accompanying editorial by researchers at the University of Michigan, the study resolves the uncertainty that persists about the full extent of risks assumed by living kidney donors and makes an important contribution to our understanding of long-term consequences of living kidney donation.
"We did this study because better knowledge of major cardiovascular events in people who become living kidney donors maintains public trust in the transplantation system, informs the choices of potential donors and recipients, and guides follow-up care to maintain good long-term health," says Dr. Garg.
The study will be published in an upcoming issue of the British Medical Journal and can be found online at BMJ.com today.
Julia Capaldi | EurekAlert!
Some brain tumors may respond to immunotherapy, new study suggests
11.12.2018 | Columbia University Irving Medical Center
Climate change and air pollution damaging health and causing millions of premature deaths
30.11.2018 | International Institute for Applied Systems Analysis (IIASA)
The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.
Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...
What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...
A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.
The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...
A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.
Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...
Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...
12.12.2018 | Event News
10.12.2018 | Event News
06.12.2018 | Event News
14.12.2018 | Power and Electrical Engineering
14.12.2018 | Physics and Astronomy
14.12.2018 | Physics and Astronomy