Memory and brain scan tests were performed on 85 people with mild cognitive impairment (MCI) who were part of a larger study called the Alzheimer’s Disease Neuroimaging Initiative. The tests included an episodic memory test, in which a participant must correctly recall a list of words. Blood tests were given to measure which form of the APOE gene people had, since one form of the gene is associated with Alzheimer’s disease.
MRI brain scans were also used to measure the size of a participant’s hippocampus, the part of the brain responsible for learning and memory. Proteins thought to play a role in Alzheimer’s disease, called tau or beta-amyloid, were also measured. Finally, a PET brain scan was taken to detect metabolic abnormalities in the brain that might signal Alzheimer’s disease.
“Each of these tests have independently shown promise in predicting disease progression, however, prior to the Alzheimer’s Disease Neuroimaging Initiative, they had never been compared to one another in the same study before,” said study author Susan M. Landau, PhD, with the University of California-Berkeley and a member of the American Academy of Neurology.
Participants were between the ages of 55 and 90 and were followed for an average of 1.9 years. During that time, 28 of the participants developed Alzheimer’s disease.
People who showed abnormal results on both PET scans and episodic memory tests were nearly 12 times more likely to develop Alzheimer’s disease than those who scored normally on both measures.
“Because people with MCI decline at different rates and some never go on to develop Alzheimer’s disease, there is a need for tools that can better predict who might benefit most from treatment,” said Landau. “When we compared all of the predictors, these two tests most accurately predicted who developed Alzheimer’s.”
The study was supported by the National Institutes of Health and the Dana Foundation.
The American Academy of Neurology, an association of more than 22,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as multiple sclerosis, restless legs syndrome, Alzheimer’s disease, narcolepsy and stroke.
For more information about the American Academy of Neurology, visit http://www.aan.com.
Rachel L. Seroka | American Academy of Neurology
Drought hits rivers first and more strongly than agriculture
06.09.2018 | Max-Planck-Institut für Biogeochemie
Landslides triggered by human activity on the rise
23.08.2018 | European Geosciences Union
The Fraunhofer FEP has been involved in developing processes and equipment for cleaning, sterilization, and surface modification for decades. The CleanHand Network for development of systems and technologies to clean surfaces, materials, and objects was established in May 2018 to bundle the expertise of many partnering organizations. As a partner in the CleanHand Network, Fraunhofer FEP will present the Network and current research topics of the Institute in the field of hygiene and cleaning at the parts2clean trade fair, October 23-25, 2018 in Stuttgart, at the booth of the Fraunhofer Cleaning Technology Alliance (Hall 5, Booth C31).
Test reports and studies on the cleanliness of European motorway rest areas, hotel beds, and outdoor pools increasingly appear in the press, especially during...
The building blocks of matter in our universe were formed in the first 10 microseconds of its existence, according to the currently accepted scientific picture. After the Big Bang about 13.7 billion years ago, matter consisted mainly of quarks and gluons, two types of elementary particles whose interactions are governed by quantum chromodynamics (QCD), the theory of strong interaction. In the early universe, these particles moved (nearly) freely in a quark-gluon plasma.
This is a joint press release of University Muenster and Heidelberg as well as the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt.
Then, in a phase transition, they combined and formed hadrons, among them the building blocks of atomic nuclei, protons and neutrons. In the current issue of...
Thin-film solar cells made of crystalline silicon are inexpensive and achieve efficiencies of a good 14 percent. However, they could do even better if their shiny surfaces reflected less light. A team led by Prof. Christiane Becker from the Helmholtz-Zentrum Berlin (HZB) has now patented a sophisticated new solution to this problem.
"It is not enough simply to bring more light into the cell," says Christiane Becker. Such surface structures can even ultimately reduce the efficiency by...
A study in the journal Bulletin of Marine Science describes a new, blood-red species of octocoral found in Panama. The species in the genus Thesea was discovered in the threatened low-light reef environment on Hannibal Bank, 60 kilometers off mainland Pacific Panama, by researchers at the Smithsonian Tropical Research Institute in Panama (STRI) and the Centro de Investigación en Ciencias del Mar y Limnología (CIMAR) at the University of Costa Rica.
Scientists established the new species, Thesea dalioi, by comparing its physical traits, such as branch thickness and the bright red colony color, with the...
Scientists have succeeded in observing the first long-distance transfer of information in a magnetic group of materials known as antiferromagnets.
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25.09.2018 | Life Sciences
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