Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study finds pigs susceptible to virulent ebolavirus can transmit the virus to other animals

13.05.2011
Canadian investigators have shown that a species of ebolavirus from Zaire that is highly virulent in humans can replicate in pigs, cause disease, and be transmitted to animals previously unexposed to the virus. The findings are published in The Journal of Infectious Diseases and are now available online.

In order to prevent human outbreaks of Ebola hemorrhagic fever, it is important to identify animal species that replicate and transmit the virus to other animals and, potentially, people. Zaire ebolavirus, one of several species of the virus, has a fatality rate as high as 90 percent in humans. Antibodies to another species not associated with human disease, known as Reston ebolavirus, have been found in pig farmers in the Philippines, suggesting pigs may be able to transmit virulent ebolavirus to humans as well.

This study, led by Gary P. Kobinger, PhD, of the Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, and Hana Weingartl, PhD, of the National Centre for Foreign Animal Disease at the Canadian Food Inspection Agency, investigated whether Zaire ebolavirus, like Reston ebolavirus, could replicate and cause disease in pigs and be transmitted to other animals. Using domesticated pigs, the researchers first evaluated virus replication, pathogenicity, and shedding.

Following mucosal exposure to Zaire ebolavirus, the pigs replicated the virus in high amounts, mainly in the respiratory tract. Shedding of the virus from nasal mucosa was detected for up to 14 days post-infection, and severe lung disease was observed. The study also showed that the virus was transmitted to all previously unexposed pigs co-habiting with the infected animals.

The study authors suggest that domesticated pigs are susceptible to Zaire ebolavirus through mucosal infection and that the pigs' accompanying severe respiratory disease is associated with shedding of high viral loads into the environment, exposing uninfected pigs to the infection. In contrast to the systemic syndrome affecting multiple organs that often leads to shock and death in primates, they noted, the respiratory syndrome that develops in pigs could be mistaken for other porcine respiratory diseases.

In an accompanying editorial, Daniel G. Bausch, MD, MPH & TM, of the Tulane School of Public Health and Tropical Medicine in New Orleans, noted that the study's findings raise important questions for additional research on ebolavirus. The results described in the study are "cause for consideration, for further scientific study" but are not cause for panic, Dr. Bausch wrote.

Fast Facts:

1. Zaire ebolavirus, one of several species of ebloavirus, has a fatality rate as high as 90 percent in humans.

2. Antibodies to Reston ebolavirus, a species of the virus not associated with disease in humans, have been found in pig farmers in the Philippines.

3. In this study, pigs exposed to Zaire ebolavirus became infected and transmitted the infection to previously unexposed pigs.

"Replication, Pathogenicity, Shedding, and Transmission of Zaire ebolavirus in Pigs" http://www.oxfordjournals.org/our_journals/jid/jir077.pdf

Editorial commentary http://www.oxfordjournals.org/our_journals/jid/jir201.pdf

Founded in 1904, The Journal of Infectious Diseases is the premier publication in the Western Hemisphere for original research on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune mechanisms. Articles in JID include research results from microbiology, immunology, epidemiology, and related disciplines. JID is published under the auspices of the Infectious Diseases Society of America (IDSA). Based in Arlington, Va., IDSA is a professional society representing more than 9,000 physicians and scientists who specialize in infectious diseases. For more information, visit www.idsociety.org.

John Heys | EurekAlert!
Further information:
http://www.idsociety.org

More articles from Studies and Analyses:

nachricht Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern

nachricht Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

Staying in Shape

16.08.2018 | Life Sciences

Diving robots find Antarctic seas exhale surprising amounts of carbon dioxide in winter

16.08.2018 | Earth Sciences

Protein droplets keep neurons at the ready and immune system in balance

16.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>