The study will appear in the June issue of the journal Environmental Toxicology and Chemistry and is the first to test multiple PBDE mixtures for changes in behavior, physical malformations and mortality on zebra fish.
PBDEs are found in many common household products from blankets to couches to food wrappers. Lab tests have shown that PBDEs have been found in human breast milk and cord blood. Previous studies have showed children with high levels of PBDEs in their umbilical cord at birth scored lower on tests between one and six years of age. In 2006, the state of California started prohibiting the use of PBDEs.
The family of PBDEs consists of more than 200 possible substances, which are called congeners. Congeners are considered low if they average between 1 to 5 bromine atoms per molecule.
The Baylor researchers tested six PBDE congeners for developmental effects on embryonic zebra fish. Changes in behavior, physical malformations and mortality were recorded daily for seven days.
The results showed:
• Lower brominated congeners were more toxic than higher brominated congeners.
• Embryos were most sensitive to two particular types of PBDE exposures, the two lowest brominated congeners of the six tested. Both induced a curved body axis and eventually death.
• In all, four of the six congeners tested caused developmental malformations, such as a curved body axis and pulmonary edema. Five of the six caused alterations in behaviors, such as decreased swimming rates and increased spontaneous movement in the embryo.
“While most PBDEs have either been banned or phased out throughout the world, it may be more beneficial to identify congeners of concern rather than replacing these compounds with chemicals of unknown biological interactions,” said Dr. Erica Bruce, assistant professor of environmental science at Baylor who is an expert in environmental chemicals and their effects on public health. “Alterations in early behavior may potentially be due to disruption of thyroid hormones. Thyroid hormones play a vital role in the development of the cholinergic system and this study gives insight into biological interaction within a few hours of exposure. The observed hyperactivity may be due to overstimulation of the cholinergic system,” Bruce said.
Matt Pene | Newswise Science News
Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern
Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...
The quality of materials often depends on the manufacturing process. In casting and welding, for example, the rate at which melts solidify and the resulting microstructure of the alloy is important. With metallic foams as well, it depends on exactly how the foaming process takes place. To understand these processes fully requires fast sensing capability. The fastest 3D tomographic images to date have now been achieved at the BESSY II X-ray source operated by the Helmholtz-Zentrum Berlin.
Dr. Francisco Garcia-Moreno and his team have designed a turntable that rotates ultra-stably about its axis at a constant rotational speed. This really depends...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
14.08.2018 | Information Technology
14.08.2018 | Life Sciences
14.08.2018 | Life Sciences