Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study discovers why females fare better than males after traumatic injury

01.09.2010
Scott & White Healthcare physicians discover important finding in treatment of hemorrhagic shock

A study published in the September 2010 issue of SHOCK by Dr. Ed W. Childs and colleagues at Scott & White Healthcare looks at how female versus male rats fared after suffering a trauma and subsequent hemorrhagic shock who were given Estradiol (estrogen). In the study, the Estradiol prevented vascular permeability following hemorrhagic shock.

"We've always known that females fare better than males after traumatic injury, but we never knew why, now we know a potential mechanism," said Ed W. Childs, M.D., professor of surgery at the Texas A&M Health Science Center College of Medicine, and vice chairman of research in the department of surgery at Scott & White Healthcare. "This study proved that estrogen receptors on the mitochondria of our cells actually help protect these cells on females after injury. But, if you block those estrogen receptors, they perform like those of a male."

Examples of shock can include: car accident, falls that may include a severe trauma, and any injury that causes bleeding. Shock (level IV) is defined as 40% blood volume loss and a systolic blood pressure under 90.

Scott & White is the only designated Level I Trauma Center between Dallas and Austin, Texas. In order to maintain a Level I Trauma designation, performing clinical and bench research is a requirement.

"Getting our study published in such a prestigious national journal as SHOCK shows our long-standing commitment to providing patients in need of Level I trauma care in Central Texas with the latest cutting-edge medical research and care," said Dr. Childs.

Level 1 Trauma programs provide the highest level of specialty care available and meet stringent national standards of performance. Access to a trauma center is strongly associated with improving a critically-injured patient's chance of survival.

The SHOCK is a journal on Injury, Inflammation and Sepsis: Laboratory and Clinical Approaches. More information can be found at www.shockjournal.org.

Dr. Childs specializes in the treatment of hemorrhagic shock, trauma prevention, and general surgery.

For access to the full study in PubMed: 17beta-estradiol mediated protection against vascular leak after hemorrhagic shock: role of estrogen receptors and apoptotic signaling.
Childs, EW, Tharakan B, Hunter FA, Smythe WR
Shock. 2010 Sep; 34(3):229-35.
PMID: 20160663 [PubMed - in process]

Katherine Voss | EurekAlert!
Further information:
http://www.sw.org

Further reports about: Healthcare Trauma estradiol estrogen receptor shock

More articles from Studies and Analyses:

nachricht Researchers simplify tiny structures' construction drip by drip
12.11.2018 | Princeton University, Engineering School

nachricht Mandibular movement monitoring may help improve oral sleep apnea devices
06.11.2018 | Elsevier

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

Im Focus: Coping with errors in the quantum age

Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly

The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

How algae and carbon fibers could sustainably reduce the athmospheric carbon dioxide concentration

14.11.2018 | Life Sciences

NIH scientists illuminate causes of hepatitis b virus-associated acute liver failure

14.11.2018 | Life Sciences

The unintended consequences of dams and reservoirs

14.11.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>