Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study discovers why females fare better than males after traumatic injury

01.09.2010
Scott & White Healthcare physicians discover important finding in treatment of hemorrhagic shock

A study published in the September 2010 issue of SHOCK by Dr. Ed W. Childs and colleagues at Scott & White Healthcare looks at how female versus male rats fared after suffering a trauma and subsequent hemorrhagic shock who were given Estradiol (estrogen). In the study, the Estradiol prevented vascular permeability following hemorrhagic shock.

"We've always known that females fare better than males after traumatic injury, but we never knew why, now we know a potential mechanism," said Ed W. Childs, M.D., professor of surgery at the Texas A&M Health Science Center College of Medicine, and vice chairman of research in the department of surgery at Scott & White Healthcare. "This study proved that estrogen receptors on the mitochondria of our cells actually help protect these cells on females after injury. But, if you block those estrogen receptors, they perform like those of a male."

Examples of shock can include: car accident, falls that may include a severe trauma, and any injury that causes bleeding. Shock (level IV) is defined as 40% blood volume loss and a systolic blood pressure under 90.

Scott & White is the only designated Level I Trauma Center between Dallas and Austin, Texas. In order to maintain a Level I Trauma designation, performing clinical and bench research is a requirement.

"Getting our study published in such a prestigious national journal as SHOCK shows our long-standing commitment to providing patients in need of Level I trauma care in Central Texas with the latest cutting-edge medical research and care," said Dr. Childs.

Level 1 Trauma programs provide the highest level of specialty care available and meet stringent national standards of performance. Access to a trauma center is strongly associated with improving a critically-injured patient's chance of survival.

The SHOCK is a journal on Injury, Inflammation and Sepsis: Laboratory and Clinical Approaches. More information can be found at www.shockjournal.org.

Dr. Childs specializes in the treatment of hemorrhagic shock, trauma prevention, and general surgery.

For access to the full study in PubMed: 17beta-estradiol mediated protection against vascular leak after hemorrhagic shock: role of estrogen receptors and apoptotic signaling.
Childs, EW, Tharakan B, Hunter FA, Smythe WR
Shock. 2010 Sep; 34(3):229-35.
PMID: 20160663 [PubMed - in process]

Katherine Voss | EurekAlert!
Further information:
http://www.sw.org

Further reports about: Healthcare Trauma estradiol estrogen receptor shock

More articles from Studies and Analyses:

nachricht Antarctic Ice Sheet mass loss has increased
14.06.2018 | Technische Universität Dresden

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>