Researchers at Huntsman Cancer Institute (HCI) believe they may be one step closer to understanding how certain forms of colon cancer develop.
In a study using siblings who have been diagnosed with colon cancer, scientists discovered similarities on a region of a particular chromosome, referred to as 7q31. Researchers believe that piece of genetic material may be causing a subset of colon cancers that run in families.
"It's those genetic similarities in colon cancer patients that would suggest that region holds a gene that's causing colon cancer," says Deborah Neklason, PhD and lead investigator on the study. Referred to as the Cancer Genetics Network "Sibling Pair Project," Neklason and other researchers analyzed the genetic material of 82 siblings. In addition to the discovery of a potential location of a cancer-causing gene, the research also shows siblings who share this genetic region tend to develop cancer 3.8 years earlier than siblings who do not. The study findings are published in the November 1, 2008 issue of Cancer Research.
Scientists already know roughly 30 percent of all colon cancers are a direct result of an inherited gene, but less than five percent of these genes have been identified. "Those cases where the genes have been identified tend to be pretty dramatic," says Neklason. "Colon cancer develops at young ages and the cases are easier to figure out. It's the other 25 percent that's tough. These cases are more like sporadic colon cancer and are much more subtle," she says.
The findings could ultimately lead to a better understanding of the cellular process that results in cancer and its progression. It will likely pave the way for more targeted research that could someday result in a screening test to detect genetic forms of colon cancer.
When a fish becomes fluid
17.12.2018 | Institute of Science and Technology Austria
Some brain tumors may respond to immunotherapy, new study suggests
11.12.2018 | Columbia University Irving Medical Center
Different eras of civilization are defined by the discovery of new materials, as new materials drive new capabilities. And yet, identifying the best material...
Researchers from the University of Basel have reported a new method that allows the physical state of just a few atoms or molecules within a network to be controlled. It is based on the spontaneous self-organization of molecules into extensive networks with pores about one nanometer in size. In the journal ‘small’, the physicists reported on their investigations, which could be of particular importance for the development of new storage devices.
Around the world, researchers are attempting to shrink data storage devices to achieve as large a storage capacity in as small a space as possible. In almost...
The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.
Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...
What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...
A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.
The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...
12.12.2018 | Event News
10.12.2018 | Event News
06.12.2018 | Event News
19.12.2018 | Materials Sciences
19.12.2018 | Materials Sciences
19.12.2018 | Life Sciences