Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Shift work in teens linked to increased multiple sclerosis risk

18.10.2011
Circadian disruption and sleep restriction contributing factors

Researchers from Sweden have uncovered an association between shift work and increased risk of multiple sclerosis (MS). Those who engage in off-hour employment before the age of 20 may be at risk for MS due to a disruption in their circadian rhythm and sleep pattern. Findings of this novel study appear today in Annals of Neurology, a journal published by Wiley-Blackwell on behalf of the American Neurological Association and Child Neurology Society.

Previous research has determined that shift work—working during the night or rotating working hours—increases the risk of cardiovascular disease, thyroid disorders, and cancer. Circadian disruption and sleep restriction are associated with working night shifts; these factors are believed to disturb melatonin secretion and increase inflammatory responses, promoting disease states. MS is a central nervous system autoimmune inflammatory disorder that has an important environmental component, thus investigating lifestyle risk factors, such as sleep loss related to shift work, is an important objective and the focus of the current study.

Dr. Anna Karin Hedström and colleagues from the Karolinska Institutet in Stockholm analyzed data from two population-based studies—one with 1343 incident cases of MS and 2900 controls and another with 5129 prevalent MS cases and 4509 controls. The team compared the occurrence of MS among study subjects exposed to shift work at various ages against those who had never been exposed. All study subjects resided in Sweden and were between the ages of 16 and 70. Shift work was defined as permanent or alternating working hours between 9 p.m. and 7 a.m.

"Our analysis revealed a significant association between working shift at a young age and occurrence of MS," explains Dr. Hedström. "Given the association was observed in two independent studies strongly supports a true relationship between shift work and disease risk." Results showed that those in the incident MS cohort who had worked off-hour shifts for three years or longer before age 20 had a 2 fold-risk of developing MS compared with those who never worked shifts. Similarly, subjects in the prevalent cohort who engaged in shift work as teens had slightly more than a 2-fold risk of MS than subjects who never worked shifts.

The authors suggest that disruption of circadian rhythm and sleep loss may play a role in the development of MS; however the exact mechanisms behind this increased risk remain unclear and further study is needed.

This study is published in Annals of Neurology. Media wishing to receive a PDF of this article may contact healthnews@wiley.com.

Full citation:"Shift Work at Young Age is Associated with Increased Risk for Multiple Sclerosis." Anna Karin Hedström, Torbjörn Åkerstedt, Jan Hillert, Tomas Olsson and Lars Alfredsson. Annals of Neurology; Published Online: October 18, 2011 (DOI:10.1002/ana.22597). http://doi.wiley.com/10.1002/ana.22597

Author Contact: To arrange an interview with Dr. Hedström, please contact Camilla Wernersson with the Karolinska Institutet at camilla.wernersson@ki.se.

About the Journal

Annals of Neurology, the official journal of the American Neurological Association and the Child Neurology Society, publishes articles of broad interest with potential for high impact in understanding the mechanisms and treatment of diseases of the human nervous system. All areas of clinical and basic neuroscience, including new technologies, cellular and molecular neurobiology, population sciences, and studies of behavior, addiction, and psychiatric diseases are of interest to the journal.

About Wiley-Blackwell

Wiley-Blackwell is the international scientific, technical, medical, and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and professional field and partnerships with many of the world's leading societies. Wiley-Blackwell publishes nearly 1,500 peer-reviewed journals and 1,500+ new books annually in print and online, as well as databases, major reference works and laboratory protocols. For more information, please visit http://www.wileyblackwell.com or our new online platform, Wiley Online Library (http://www.wileyonlinelibrary.com), one of the world's most extensive multidisciplinary collections of online resources, covering life, health, social and physical sciences, and humanities.

Dawn Peters | EurekAlert!
Further information:
http://www.wiley.com

More articles from Studies and Analyses:

nachricht TU Dresden biologists examine sperm quality on the basis of their metabolism
29.11.2019 | Technische Universität Dresden

nachricht Approaching the perception of touch in the brain
27.11.2019 | Max Planck Institute for Human Cognitive and Brain Sciences

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Highly charged ion paves the way towards new physics

In a joint experimental and theoretical work performed at the Heidelberg Max Planck Institute for Nuclear Physics, an international team of physicists detected for the first time an orbital crossing in the highly charged ion Pr⁹⁺. Optical spectra were recorded employing an electron beam ion trap and analysed with the aid of atomic structure calculations. A proposed nHz-wide transition has been identified and its energy was determined with high precision. Theory predicts a very high sensitivity to new physics and extremely low susceptibility to external perturbations for this “clock line” making it a unique candidate for proposed precision studies.

Laser spectroscopy of neutral atoms and singly charged ions has reached astonishing precision by merit of a chain of technological advances during the past...

Im Focus: Ultrafast stimulated emission microscopy of single nanocrystals in Science

The ability to investigate the dynamics of single particle at the nano-scale and femtosecond level remained an unfathomed dream for years. It was not until the dawn of the 21st century that nanotechnology and femtoscience gradually merged together and the first ultrafast microscopy of individual quantum dots (QDs) and molecules was accomplished.

Ultrafast microscopy studies entirely rely on detecting nanoparticles or single molecules with luminescence techniques, which require efficient emitters to...

Im Focus: How to induce magnetism in graphene

Graphene, a two-dimensional structure made of carbon, is a material with excellent mechanical, electronic and optical properties. However, it did not seem suitable for magnetic applications. Together with international partners, Empa researchers have now succeeded in synthesizing a unique nanographene predicted in the 1970s, which conclusively demonstrates that carbon in very specific forms has magnetic properties that could permit future spintronic applications. The results have just been published in the renowned journal Nature Nanotechnology.

Depending on the shape and orientation of their edges, graphene nanostructures (also known as nanographenes) can have very different properties – for example,...

Im Focus: Electronic map reveals 'rules of the road' in superconductor

Band structure map exposes iron selenide's enigmatic electronic signature

Using a clever technique that causes unruly crystals of iron selenide to snap into alignment, Rice University physicists have drawn a detailed map that reveals...

Im Focus: Developing a digital twin

University of Texas and MIT researchers create virtual UAVs that can predict vehicle health, enable autonomous decision-making

In the not too distant future, we can expect to see our skies filled with unmanned aerial vehicles (UAVs) delivering packages, maybe even people, from location...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

The Future of Work

03.12.2019 | Event News

First International Conference on Agrophotovoltaics in August 2020

15.11.2019 | Event News

Laser Symposium on Electromobility in Aachen: trends for the mobility revolution

15.11.2019 | Event News

 
Latest News

Self-driving microrobots

11.12.2019 | Materials Sciences

Innovation boost for “learning factory”: European research project “SemI40” generates path-breaking findings

11.12.2019 | Information Technology

Molecular milk mayonnaise: How mouthfeel and microscopic properties are related in mayonnaise

11.12.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>