Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Severe sepsis, new-onset AF associated with increased risk of hospital stroke, death

14.11.2011
A recent study led by researchers at Boston University School of Medicine (BUSM) shows an increased risk of stroke and mortality among patients diagnosed with severe sepsis and new-onset atrial fibrillation (AF) during hospitalization.

Allan J. Walkey, MD, assistant professor of medicine at BUSM and a pulmonologist at Boston Medical Center (BMC), is the lead author of the study, which will be published in the Journal of the American Medical Association. Walkey also will present the findings at the American Heart Association's annual Scientific Sessions in Orlando, Fla., on Sunday, Nov. 13, at 4:45 p.m. ET.

Severe sepsis is the 10th leading cause of death in the United States, and atrial fibrillation affects one in four people over the age of 40. While both are common illnesses, and chronic atrial fibrillation is a known risk factor for stroke and death, very little is known about new-onset atrial fibrillation during severe sepsis.

"The purpose of our retrospective study was to examine if a new-onset atrial fibrillation diagnosis in patients with severe sepsis was associated with an increased the risk of stroke and mortality in a hospital setting," said Walkey.

The researchers examined data, provided by the Agency for Healthcare Research and Quality, from more than three million hospitalized patients. Looking at the risks of stroke and mortality, patients with new- onset atrial fibrillation during severe sepsis had three times the risk of having a stroke and a seven percent increased risk of death during hospitalization. Almost three percent of patients with new-onset atrial fibrillation during severe sepsis had a stroke during hospitalization compared to less than one percent of those not diagnosed with the condition during severe sepsis.

The data also showed that 56 percent of patients with severe sepsis and new-onset atrial fibrillation died, whereas 39 percent of patients with severe sepsis who did not develop new-onset atrial fibrillation did not. Additionally, six percent of patients with severe sepsis developed new-onset atrial fibrillation compared to less than one percent of patients who did not have severe sepsis and were hospitalized for another reason. Furthermore, among all patients with or without severe sepsis, 14 percent of all new-onset atrial fibrillation cases occurred in patients with severe sepsis.

"It is projected that one million Americans will have severe sepsis this year, and based on our data, approximately 60,000 people will develop new-onset atrial fibrillation," said Walkey. "There are currently no guidelines on how best to care for these specific patients, but this study is a call to action that this under-recognized potential complication of severe sepsis requires further investigation on how to treat these critically ill patients."

This research was funded by that National Institutes of Health's National Heart Lung and Blood Institute.

About Boston University School of Medicine

Originally established in 1848 as the New England Female Medical College, and incorporated into Boston University in 1873, Boston University School of Medicine today is a leading academic medical center with an enrollment of more than 700 medical students and more than 800 masters and PhD students. Its 1,246 full and part-time faculty members generated more than $335 million in funding in the 2009-2010 academic year for research in amyloidosis, arthritis, cardiovascular disease, cancer, infectious disease, pulmonary disease and dermatology among others. The School is affiliated with Boston Medical Center, its principal teaching hospital, the Boston and Bedford Veterans Administration Medical Centers and 16 other regional hospitals as well as the Boston HealthNet.

Jenny Eriksen Leary | EurekAlert!
Further information:
http://www.bmc.org

More articles from Studies and Analyses:

nachricht Self-organising system enables motile cells to form complex search pattern
07.05.2019 | Westfälische Wilhelms-Universität Münster

nachricht Mouse studies show minimally invasive route can accurately administer drugs to brain
02.05.2019 | Johns Hopkins Medicine

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Self-repairing batteries

UTokyo engineers develop a way to create high-capacity long-life batteries

Engineers at the University of Tokyo continually pioneer new ways to improve battery technology. Professor Atsuo Yamada and his team recently developed a...

Im Focus: Quantum Cloud Computing with Self-Check

With a quantum coprocessor in the cloud, physicists from Innsbruck, Austria, open the door to the simulation of previously unsolvable problems in chemistry, materials research or high-energy physics. The research groups led by Rainer Blatt and Peter Zoller report in the journal Nature how they simulated particle physics phenomena on 20 quantum bits and how the quantum simulator self-verified the result for the first time.

Many scientists are currently working on investigating how quantum advantage can be exploited on hardware already available today. Three years ago, physicists...

Im Focus: Accelerating quantum technologies with materials processing at the atomic scale

'Quantum technologies' utilise the unique phenomena of quantum superposition and entanglement to encode and process information, with potentially profound benefits to a wide range of information technologies from communications to sensing and computing.

However a major challenge in developing these technologies is that the quantum phenomena are very fragile, and only a handful of physical systems have been...

Im Focus: A step towards probabilistic computing

Working group led by physicist Professor Ulrich Nowak at the University of Konstanz, in collaboration with a team of physicists from Johannes Gutenberg University Mainz, demonstrates how skyrmions can be used for the computer concepts of the future

When it comes to performing a calculation destined to arrive at an exact result, humans are hopelessly inferior to the computer. In other areas, humans are...

Im Focus: Recording embryonic development

Scientists develop a molecular recording tool that enables in vivo lineage tracing of embryonic cells

The beginning of new life starts with a fascinating process: A single cell gives rise to progenitor cells that eventually differentiate into the three germ...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

SEMANTiCS 2019 brings together industry leaders and data scientists in Karlsruhe

29.04.2019 | Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

 
Latest News

Summit charts a course to uncover the origins of genetic diseases

22.05.2019 | Life Sciences

New study finds distinct microbes living next to corals

22.05.2019 | Life Sciences

Stellar waltz with dramatic ending

22.05.2019 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>