This is contrary to epidemiological data suggesting that these women are at greater risk of certain complications of pregnancy, including hypertension, gestational diabetes, premature birth, and placenta abnormalities.
In the largest single-center study of older women who became pregnant from egg donation, Mark V. Sauer, MD; Daniel H. Kort, MD; and colleagues studied 101 women age 50 and over. They compared their pregnancy results with those of egg-donation recipients age 42 and younger. The two groups were evaluated for significant differences in perinatal complications, gestational age at delivery, baby's birth weight, and mode of delivery.
Although the women all received their fertility treatment at Columbia University Center for Reproductive Care, their prenatal care and delivery often took place elsewhere.
Both older and younger women had similar rates of gestational hypertension, diabetes, cesarean delivery, and premature birth. Two women in the older group experienced a serious adverse effect. A 56-year-old woman developed heavy vaginal bleeding at 29 weeks of pregnancy and had to deliver by emergency cesarean hysterectomy at 2 weeks later. She recovered with no further complications. A 49-year-old woman (who would have been age 50 at term) died following acute cardiac arrest in her first trimester. The researchers believe that her death was unrelated to her pregnancy and more likely attributable to her heavy smoking habit, which she had not disclosed to her doctors.
The study concluded that all women who use egg donation to become pregnant are at an elevated risk for obstetrical complications, particularly hypertensive disorders and cesarean section; but women over age 50 do not appear to face any greater risk than their younger counterparts.
"It is imperative that all older women undergo thorough medical screening before attempting pregnancy to ensure the best possible outcome," said Mark Sauer, professor of obstetrics and gynecology at Columbia University Medical Center (CUMC). "But, really, that should apply to younger women, as well."
"Although many social and ethical questions surround the use of assisted reproductive technology by this age group, the current study confirms the high success rate and relative safety of such pregnancies in well-cared-for women," said Daniel H. Kort, a postdoctoral fellow in obstetrics and gynecology.
The study's authors are Daniel H. Kort, MD (CUMC); Jennifer Gosselin, PhD (CUMC); Janet M. Choi, MD (CUMC); Melvin H. Thornton, MD; Jane Cleary-Goldman, MD (Mount Sinai Medical Center); and Mark V. Sauer, MD (CUMC).
The researchers report no financial or other conflict of interest.
Columbia University Medical Center provides international leadership in basic, pre-clinical, and clinical research; in medical and health sciences education; and in patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the College of Physicians and Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. Established in 1767, Columbia's College of Physicians and Surgeons was the first institution in the country to grant the M.D. degree and is among the most selective medical schools in the country. Columbia University Medical Center is home to the largest medical research enterprise in New York City and State and one of the largest in the United States. For more information, please visit www.cumc.columbia.edu.
Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern
Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Physics and Astronomy
17.08.2018 | Information Technology
17.08.2018 | Life Sciences