Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Resveratrol supplements cause pancreatic problems in developing fetus

03.06.2014

A collaborative study from Oregon Health & Science University and the University of Colorado-Denver warns against use of Resveratrol supplements by pregnant women

A widely available dietary supplement that had been considered safe — and that some claim provides anti-aging and other health benefits — caused significant developmental abnormalities in the pancreas of offspring of pregnant monkeys who were given the supplement, according to a study published today in the FASEB Journal, from the Federation of American Societies of Experimental Biology.

Because of the results, authors of the study strongly recommend that pregnant women or women who might get pregnant avoid taking the supplement.

The supplement contains resveratrol, which is a plant compound found in the skin of red grapes and in peanuts and berries, among other plants. The supplement form of the compound has been available in pharmacies and health food stores for years, with claims that it has a wide range of health benefits. The compound is thought to be an anti-oxidant and an anti-inflammatory, and some animal studies do confirm some benefits. All previous studies had found it to be safe in humans.

Researchers at Oregon Health & Science University's Oregon National Primate Research Center and the University of Colorado-Denver were focusing on some of those potential benefits when they began studying the compound in monkeys. They were specifically focusing on whether resveratrol might help protect against some of the effects of a Western high-fat, high-calorie diet on pregnant women — effects that include complications during pregnancy and long-term health complications for the baby.

The research indicated that resveratrol did provide some real benefits in the pregnant monkeys, including improved blood flow through the placenta to the fetus. Placental abnormalities contribute to many of the pregnancy complications and health issues with babies of obese women who eat an unhealthy Western diet.

But the researchers also found an effect that surprised them — resveratrol had a significantly negative effect on the development of the pancreas in the monkey fetus. The pancreas is critical for the body's regulation of blood glucose.

“In the beginning, the results were promising and we had hoped to find a natural supplement that could improve the pregnancy complications. However, the negative impact on the pancreas is really concerning," said Kevin Grove, Ph.D., head of the Division of Diabetes, Obesity and Metabolism at ONPRC and a senior co-author of the study. "It immediately raised an alarm."

Antonio Frias, M.D., is director of the diabetes and pregnancy program at OHSU’s Center for Women’s Health, a scientist at ONPRC and a senior co-author of the study. He has not recommended that pregnant women take resveratrol in the past. But he thinks it's especially important now for obstetric providers to ask pregnant women or reproductive-age women whether they are taking it.

"I think it's something obstetric providers should now ask and they should advise women to stop taking it," Frias said.

Frias said the study results point to the benefits of research of this type in animals. It could have taken years for human clinical trials to uncover this potential effect — if they had uncovered it at all, he said. “Although we are uncertain of the long-term impact of these changes, problems with pancreatic development might not have been evident for many years after the child was born,” he said.

Researchers will continue to study the resveratrol effects on non-human primates to determine if there might be a way to isolate the positive effects while preventing the negative impact on pancreatic development.

The research was supported by the National Institutes of Health (grant #s R24 DK090964 and P51-OD-011092).

About OHSU

Oregon Health & Science University is a nationally prominent research university and Oregon’s only public academic health center. It serves patients throughout the region with a Level 1 trauma center and nationally recognized Doernbecher Children’s Hospital. OHSU operates dental, medical, nursing and pharmacy schools that rank high both in research funding and in meeting the university’s social mission. OHSU’s Knight Cancer Institute helped pioneer personalized medicine through a discovery that identified how to shut down cells that enable cancer to grow without harming healthy ones. OHSU Brain Institute scientists are nationally recognized for discoveries that have led to a better understanding of Alzheimer’s disease and new treatments for Parkinson’s disease, multiple sclerosis and stroke. OHSU’s Casey Eye Institute is a global leader in ophthalmic imaging, and in clinical trials related to eye disease.

About ONPRC

The Oregon National Primate Research Center is one of the eight National Primate Research Centers supported by NIH. ONPRC is a registered research institution, inspected regularly by the United States Department of Agriculture. It operates in compliance with the Animal Welfare Act and has an assurance of regulatory compliance on file with the National Institutes of Health. The ONPRC also participates in the voluntary accreditation program overseen by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC).

Todd Murphy | Eurek Alert!
Further information:
http://www.ohsu.edu

Further reports about: Health OHSU ONPRC Resveratrol monkeys pancreas pancreatic pregnancy pregnant supplements

More articles from Studies and Analyses:

nachricht Some brain tumors may respond to immunotherapy, new study suggests
11.12.2018 | Columbia University Irving Medical Center

nachricht Climate change and air pollution damaging health and causing millions of premature deaths
30.11.2018 | International Institute for Applied Systems Analysis (IIASA)

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Data use draining your battery? Tiny device to speed up memory while also saving power

The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.

Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...

Im Focus: An energy-efficient way to stay warm: Sew high-tech heating patches to your clothes

Personal patches could reduce energy waste in buildings, Rutgers-led study says

What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

Data use draining your battery? Tiny device to speed up memory while also saving power

14.12.2018 | Power and Electrical Engineering

Tangled magnetic fields power cosmic particle accelerators

14.12.2018 | Physics and Astronomy

In search of missing worlds, Hubble finds a fast evaporating exoplanet

14.12.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>