Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study finds genetic testing may help people with severe type of migraine

04.12.2007
People with a severe type of migraine in which one side of the body becomes weak should consider genetic testing, according to research that has found familial genes for this type of migraine in people who did not have family members experiencing the problem. The findings are published in the December 4, 2007, issue of Neurology®, the medical journal of the American Academy of Neurology.

“Our findings have important clinical implications,” said study author Michel D. Ferrari, MD, PhD, with Leiden University Medical Centre in the Netherlands. “Since many people with this type of migraine are initially misdiagnosed and not given the proper treatment, understanding the genetic basis of this type of migraine may help clinicians in diagnosing and treating the problem. Most patients are initially diagnosed with epilepsy, stroke or other disorders and are treated accordingly with non-effective medications that are associated with a high risk of side effects rather than with effective agents to treat migraine.”

For the study, genetic testing was performed on 39 men and women with sporadic hemiplegic migraine, which is a rare, often severe subtype of migraine with aura in which attacks are associated with a weakness affecting one side of the body. The participants, who had no known family members with this type of migraine, were screened for mutations in the three known genes for familial hemiplegic migraine: the CACNA1A gene, the ATPIA2 gene, and the SCN1A gene.

The study found variants of these familial genes in 18 percent of the study participants. Variants in the ATPIA2 gene were the most prevalent.

Ferrari says screening for familial genes in people with this type of sporadic migraine may also help to enable counseling and prevent unnecessary treatment with potentially harmful drugs.

“Our findings reinforce the growing evidence that familial and sporadic hemiplegic migraine along with normal migraine have some shared gene pathways. Unraveling these pathways may help to identify new treatment options,” said Ferrari.

Angela Babb | EurekAlert!
Further information:
http://www.aan.com

More articles from Studies and Analyses:

nachricht Researchers simplify tiny structures' construction drip by drip
12.11.2018 | Princeton University, Engineering School

nachricht Mandibular movement monitoring may help improve oral sleep apnea devices
06.11.2018 | Elsevier

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Purdue cancer identity technology makes it easier to find a tumor's 'address'

16.11.2018 | Health and Medicine

Good preparation is half the digestion

16.11.2018 | Life Sciences

Microscope measures muscle weakness

16.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>