It is well known that tobacco consumption causes a respiratory disease called chronic obstructive pulmonary disease (COPD), characterized by formation of emphysema and progressive destruction of the lung.
When pulmonary vessels are altered in this disease, life expectancy of the patients worsens. It has not been possible to establish the cause, but it has been attributed to low oxygen concentration in the blood.
However, changes in the pulmonary vessels have also been found in COPD patients with normal oxygen concentrations. These abnormalities mainly consist of the thickening of the internal coat of pulmonary arteries, resulting in a decrease of the arterial lumen size.
The cellular and extracellular components that are involved in this enlargement are unknown.
A study published in this month’s European Respiratory Journal (ERJ) by Prof. J.A. Barbera of the Servei de Pneumologia Hospital Clinic in Barcelona, Spain, and colleagues was designed to characterize the changes occurring in pulmonary arteries of patients with mild COPD and in smokers who have not yet developed the disease.
The researchers found that the thickening of the wall is mainly due to the proliferation of smooth muscle cells with synthetic capacity, as well as elastin and collagen deposition.
These alterations occur in both groups of patients to the same degree.
These findings indicate that cellular and extracellular changes of pulmonary vessels may be originated at an early stage in cigarette smoke-induced respiratory disease, suggesting that tobacco consumption is possibly the direct cause of these changes
Prof. J.A. Barbera | Daily University Science News
Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern
Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Physics and Astronomy
17.08.2018 | Information Technology
17.08.2018 | Life Sciences