Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New tool improves prediction of stroke risk

26.01.2007
A new simple scoring system for use by physicians predicts early risk of stroke following a serious condition named transient ischemic attack, known as TIA and also called a "mini-stroke," according to a study published in this week's "Lancet."

The lead author of the study is S. Claiborne Johnston, MD, a neurologist at UCSF Medical Center and associate professor in the UCSF School of Medicine.

About 240,000 TIAs are diagnosed every year in the United States and about 70,000 in the United Kingdom. A TIA is a serious condition caused by temporary reduction in blood and oxygen supply to part of the brain that can cause acute symptoms such as loss of vision, leg and arm weakness, slurring of speech and loss of consciousness. A TIA is sometimes called a mini-stroke because symptoms are the same as a stroke. The severe symptoms of TIA normally last up to a few hours, and all symptoms disappear within 24 hours. Because of the short duration, many people who experience TIAs do not go to see a doctor, or if they do, they are not always treated with urgency.

Recent studies have shown that 4–20 percent of these patients will have a stroke within 90 days of a TIA, and half within the first two days. Identification of those at highest and lowest risk of stroke after a TIA would help physicians decide who needs to come into the hospital right away and who can be treated as an outpatient, according to Johnston. However, it has not been possible to estimate individual risk with sufficient accuracy to guide these clinical decisions.

Two current prognostic scores have been proposed: the California score, which estimates the risk of stroke within 90 days after presentation of TIA, and the ABCD score, which estimates the risk within seven days. However, Johnston emphasized, estimating the risk of stroke within two days after TIA is often most relevant for decisions about necessity of urgent evaluation and observation.

Johnston and colleagues tested the two existing prognostic scores in large independent groups from different populations from the U.S. and the U.K., comparing predictions of stroke risk at two, seven and 90 days after TIA. Since both previous prognostic scores predicted stroke risk reliably across a wide range of populations and contained several similar components, the researchers generated a new unified score for optimum two-day risk. The new score, ABCD-squared, was a more accurate predictor of risk of stroke than either of the two previous scores, creating a single standard for use in clinical care and public education.

"Right now, there is no consensus as to who gets admitted to the hospital or has other medical intervention after a TIA," Johnston said. "We are hoping this will be a useful tool for emergency department physicians as well as those in clinics." He added that this would also be useful for patients, especially those with diabetes and the elderly.

This new scoring method assigns points to each patient on the basis of five clinical features: high blood pressure, unilateral weakness, speech impairment without weakness, diabetes and being older. The sum of the points delineate groups at high, moderate, or low-risk.

Johnston noted that while intervention such as hospitalization is costly, in the long run it could result in a cost savings because follow-up to a stroke usually involves lengthy and costly inpatient rehabilitation. Also, if the patient does have a stroke while he or she is being observed, the stroke can be treated with clot-busting drugs immediately.

In the "Lancet" report, the authors conclude: "Findings of many studies have confirmed that the short-term risk of stroke is raised after TIA. The ABCD2 score allows identification of groups at especially high risk, in whom aggressive evaluation and urgent intervention is clearly justified."

Carol Hyman | EurekAlert!
Further information:
http://www.ucsf.edu/

More articles from Studies and Analyses:

nachricht Study relating to materials testing Detecting damages in non-magnetic steel through magnetism
23.07.2018 | Technische Universität Kaiserslautern

nachricht Innovative genetic tests for children with developmental disorders and epilepsy
11.07.2018 | Christian-Albrechts-Universität zu Kiel

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

Staying in Shape

16.08.2018 | Life Sciences

Diving robots find Antarctic seas exhale surprising amounts of carbon dioxide in winter

16.08.2018 | Earth Sciences

Protein droplets keep neurons at the ready and immune system in balance

16.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>